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The Toll-Like Receptor Radical Cycle Pathway – the key to drug treatment for secondary chronic fatigue
Review abstract: In this review we discuss that peripheral and central activation of the Toll-like receptor 2/4 (TLR2/4) Radical Cycle may underpin the pathophysiology of immune-related chronic fatigue secondary to other medical diseases and conditions. The TLR Radical Cycle plays … Continue reading
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Tagged antioxidants, chronic fatigue, damage associated molecular patterns, DAMPs, inflammation, lipopolysaccharides, Oxidative and nitrosative stress, TLR2/4, Toll-like receptor 2/4
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Anti-citrullinated protein antibodies in CFS
The Vermont CFIDS Association reports on a recent pilot study and invites contributions to enable further research: While preliminary, the results from this University of Vermont study is the first evidence for the potential existence of autoantibodies in ME/CFS, indicative … Continue reading
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Tagged anti-citrullinated protein antibodies, autoantibodies, David Maughan, George Webb, immune system dysfunction, inflammation, Mercedes Rincon, Terence Naumann, Vermont CFIDS Association
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Luteolin – potential treatment for brain fog, inflammation & obesity?
Review article: Brain “fog” is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain “fog” characterizes patients with autism spectrum disorders (ASDs), celiac disease, chronic … Continue reading
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Tagged brain fog, flavonoids, inflammation, luteolin, olive fruit extract
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ME/CFS – predisposed to inflammation?
Inflammation is a hot topic in ME/CFS yet no one has taken a comprehensive look at its possible genetic roots. The CDC just did that – and out popped one very specific part of the immune system. Exercise studies that … Continue reading
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Tagged Cort Johnson, immune system, inflammation
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Immune and inflammation related genes in CFS
Research abstract: Recent evidence suggests immune and inflammatory alterations are important in chronic fatigue syndrome (CFS). This study was done to explore the association of functionally important genetic variants in inflammation and immune pathways with CFS. Peripheral blood DNA was … Continue reading
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Tagged Elizabeth R. Unger, genes, immune dysfunction, inflammation
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A possible bio-marker for distinguishing inflammation in IBS
Research abstract: Background: Recent studies demonstrated low-grade inflammation in patients with irritable bowel syndrome (IBS). However, these studies have been relatively small and do not enable examination of this factor in different subtypes of IBS and the possibility of confounding … Continue reading
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Tagged C-reactive protein, CRP, IBS, inflammation, Irritable bowel syndrome, subgroups
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Inflammatory hypothesis of mood spectrum
Review abstract OBJECTIVES: The present paper aimed at reviewing literature data on the inflammatory hypothesis of mood spectrum, as well as the overlapping features with some chronic rheumatologic disorders, in particular fibromyalgia and chronic fatigue syndrome. METHODS: A literature search … Continue reading
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Tagged Fibromyalgia, FM, inflammation, mood spectrum
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CFS subgroup found to have low level inflammation
CFS is characterized by profound levels of persistent/recurrent fatigue. It is proposed that chronic, low level inflammation may play a role in this fatigue. We recruited 100 untreated patients with CFS (average age 33±12) and 100 age and sex matched … Continue reading
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Tagged cytokines, inflammation, mitochondrial dysfunction, muscle fatigue
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Cytokine expression doesn’t reflect symptoms in adolsecent CFS
Highlights of Norwegian research Chronic fatigue syndrome (CFS) might be related to altered cytokine expression. A total of 120 adolescent CFS patients and 68 healthy controls were studied. Individual cytokine levels where similar across the two groups. Cytokine network parameters … Continue reading
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Tagged adolescents, cytokines, inflammation
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