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Latest News
- Towards a biomarker: Rethinking ME/CFS diagnostic reference intervals via machine learning, & the utility of activin B for defining symptom severity
- ME/CFS: From pathophysiological insights to novel therapeutic opportunities
- Unexplained exertional intolerance associated with impaired systemic oxygen extraction
- ME support group meets Montgomery 18 Sep 2019
- Survey of the experiences of children & young people with ME for NICE
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Tag Archives: immune dysfunction
Immunosignature analysis of ME/CFS – promising diagnostic biomarker
Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Oliver P Günther, Jennifer L Gardy, Phillip Stafford, Øystein Fluge, Olav Mella, Patrick Tang, Ruth R Miller, Shoshana M Parker, Stephen A Johnston, David M Patrick in Molecular Neurobiology (2018) pp 1-9 [Published online: … Continue reading
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Tagged biomarker, diagnostic marker, Dr David Patrick, Dr Oystein Fluge, immune dysfunction, immunosignature, Jennifer L Gardy, Oliver P Günther, Patrick Tang, Phillip Stafford, Prof Olav Mella, Ruth R Miller, Shoshana M Parker, Stephen A Johnston
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Association of T & NK cell phenotype with the diagnosis of ME/CFS
Research abstract: Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jose Luis Rivas, Teresa Palencia, Guerau Fernández, Milagros Garcia in Front. Immunol., 09 May 2018 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is … Continue reading
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Tagged diagnosis, Guerau Fernández, immune dysfunction, immunological profile, Jose Luis Rivas, Milagros Garcia, Natural Killer cells, NK cells, T regulatory cells, Teresa Palencia
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Investigation of mast cell toll-like receptor 3 in CFS/ME
Research abstract: Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis participants using the novel application of autoMACS magnetic separation and flow cytometry, by C Balinas, T Nguyen, S Johnston, P Smith, D Staines, S Marshall-Gradisnik in Asian … Continue reading
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Tagged C Balinas, Dr Samantha Johnston, Dr Sonya Marshall-Gradisnik, immune dysfunction, mast cells, MCPs, P Smith, Prof Donald Staines, T Nguyen, TLR3, toll-like receptors, white blood cells
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Physiological post-exertional abnormalities in ME & CFS
Review article extracts: Abstract: Post-exertional “malaise” is a hallmark symptom of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Various abnormalities, including abnormal physiological responses to exertion, can account for post-exertional “malaise” and “exercise avoidance”. Since these abnormalities are not … Continue reading
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Tagged energetics, exercise intolerance, Exercise physiology, Exercise Physiology; Energetics; Immune System, immune dysfunction, Oxidative and nitrosative stress, Post-exertional malaise
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Low NK cell activity differs in ME/CFS & MS
Research abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Multiple Sclerosis (MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS/ME and MS patients, dysfunction of the immune system … Continue reading
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Tagged Dr Sonya Marshall-Gradisnik, immune dysfunction, MS, Multiple Sclerosis, Natural Killer cells, NK cells
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Low NK Cell activity in CFS and is related to severity
Review abstract: Background: Natural killer (NK) cells act as an immune surveillance against invading pathogens and tumors. NK cell cytotoxicity (NKCC) has been reported to be decreased in patients with CFS. Methods: The objective of this review was to conduct … Continue reading
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Tagged immune dysfunction, Natural Killer cells, NK cells, severe ME
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Immune dysfunction differs in moderate and severe CFS/ME over time
Research abstract: Background: Research has identified immunological abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), a heterogeneous illness with an unknown cause and absence of diagnostic test. There have been no CFS/ME studies examining innate and adaptive immune cells longitudinally in … Continue reading
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Tagged immune dysfunction, ME Research UK, Natural Killer cells, NK cells, severe ME, Sharni Lee Hardcastle, Sonya Marshall-Gradisnik
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Dr Jacob Teitelbaum overview of research into CFS & ME
Numerous studies, including research on immunologic and hormonal changes, confirm that fibromyalgia and chronic fatigue syndrome (CFS) are painfully real illnesses. Though many insurance companies continue to deny that science so they can avoid paying healthcare and disability costs, this … Continue reading
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Tagged autonomic dysfunction, Dr Jacob Teitelbaum, Dr Mark Sivieri, energy analysis program, gamma globulin, IgG antibodies, immune dysfunction, S.H.I.N.E. protocol
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Immune and inflammation related genes in CFS
Research abstract: Recent evidence suggests immune and inflammatory alterations are important in chronic fatigue syndrome (CFS). This study was done to explore the association of functionally important genetic variants in inflammation and immune pathways with CFS. Peripheral blood DNA was … Continue reading
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Tagged Elizabeth R. Unger, genes, immune dysfunction, inflammation
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