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Tag Archives: NK cells
CFS and the immune system
Review summary: Chronic fatigue syndrome and the immune system: Where are we now?, by Fane Kojo Fosu Mensaha, Amolak Singh Bansal, Brian Ford, Geraldine Cambridge in Neurophysiologie Clinique/Clinical Neurophysiology [Available online 12 April 2017] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterised by multiple … Continue reading
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Tagged B cells, Brian Ford, cytokines, Dr Amolak Bansal, Fane Fosu Mensaha, Geraldine Cambridge, immune system, NK cells
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Calcium mobilisation in natural killer cells & cell cytotoxicity in CFS/ME
Research abstract: Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+ ) cell signalling. Reduced TRPM3 has been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with … Continue reading
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Tagged cell cytotoxicity, Dr Samantha Johnston, Dr Sonya Marshall-Gradisnik, L Clarke, Natural Killer cells, NK cells, P Smith, Prof Donald Staines, T Nguyen, TRPM3 genes
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Dysregulation of protein kinase gene expression in NK Cells in CFS
Research abstract: BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes … Continue reading
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Tagged Anu Chacko, Dr Samantha Johnston, Dr Sonja Marshall Gradisnik, Natural Killer cells, NK cells, Prof Donald Staines, protein kinase genes
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CFS/ME cell discovery may hold key to treatment
Griffith University Media release, by Louise Durack, 9 June 2016: Chronic Fatigue Syndrome cell discovery may hold key to treatment: Chronic Fatigue Syndrome researchers have discovered a cell receptor which could be a key contributing factor to CFS, providing a … Continue reading
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Tagged Australia, B Nilius, cell signalling, Dr Sonya Marshall-Gradisnik, Griffith University, lymphocytes, NK cells, P Smith, Prof Donald Staines, Receptors, T Nguyen
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Natural killer cell & SNP dysfunction in ME/CFS
Research abstract: Aim: The aim of this paper was to determine natural killer (NK) cytotoxic activity and if single nucleotide polymorphisms (SNPs) and genotypes in transient receptor potential (TRP) ion channels and acetylcholine receptors (AChRs) were present in isolated NK … Continue reading
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Tagged Dr Sonja Marshall Gradisnik, Natural Killer cells, NK cells, single nucleotide polymorphisms, SNPs
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Low NK cell activity differs in ME/CFS & MS
Research abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Multiple Sclerosis (MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS/ME and MS patients, dysfunction of the immune system … Continue reading
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Tagged Dr Sonya Marshall-Gradisnik, immune dysfunction, MS, Multiple Sclerosis, Natural Killer cells, NK cells
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Low NK Cell activity in CFS and is related to severity
Review abstract: Background: Natural killer (NK) cells act as an immune surveillance against invading pathogens and tumors. NK cell cytotoxicity (NKCC) has been reported to be decreased in patients with CFS. Methods: The objective of this review was to conduct … Continue reading
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Tagged immune dysfunction, Natural Killer cells, NK cells, severe ME
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Immune dysfunction differs in moderate and severe CFS/ME over time
Research abstract: Background: Research has identified immunological abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), a heterogeneous illness with an unknown cause and absence of diagnostic test. There have been no CFS/ME studies examining innate and adaptive immune cells longitudinally in … Continue reading
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Tagged immune dysfunction, ME Research UK, Natural Killer cells, NK cells, severe ME, Sharni Lee Hardcastle, Sonya Marshall-Gradisnik
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Dysfunction found in innate and adaptive immune systems in CFS/ME
Research abstract: Background: Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The objective of this … Continue reading
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Tagged CD8+T Cell, immune dysfunction, Natural Killer cells, NK cells, Receptors
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Characterisation of impaired NK cells in CFS/ME
Abstract OBJECTIVE Natural Killer (NK) cells are classified into different phenotypes according to the expression of the surface markers CD56 and CD16. Each NK cell phenotype has a role in the immune response through cytotoxic activity or cytokine production. Reduced … Continue reading
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Tagged cytokines, Natural Killer cells, NK cell effector function, NK cells, phenotypes
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