Tag Archives: NK cells

Naltrexone restores impaired Transient Receptor Potential Melastatin 3 ion channel function in Natural Killer Cells from ME/CFS

Naltrexone restores impaired Transient Receptor Potential Melastatin 3 ion channel function in Natural Killer Cells from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients, by Helene Cabanas,  Katsuhiko Muraki,  Donald Staines and Sonya Marshall-Gradisnik in Front. Immunol., 31 October 2019 [https://doi.org/10.3389/fimmu.2019.02545]   Research … Continue reading

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Validation of impaired TRPM3 ion channel activity in natural killer cells from CFS/ME

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients, by H Cabanas, K Muraki, C Balinas, N Eaton-Fitch, D Staines, S Marshall-Gradisnik in Mol Med. 2019 Apr … Continue reading

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Cellular immune function in ME/CFS: increased MAIT cell frequency

Cellular immune function in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jacqueline M Cliff, Elizabeth C King, Ji-Sook Lee, Nuno Sepulveda, Asia-Sofia Wolf, Caroline Kingdon, Erinna Bowman, Hazel M. Dockrell, Luis C. Nacul, Eliana Lacerda, Eleanor Riley in Front. Immunol., 16 April … Continue reading

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Loss of transient receptor potential Melastatin 3 ion channel function in natural killer cells from CFS/ME

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME patients by Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines and Sonya Marshall-Gradisnik in Molecular Medicine 2018 24:44 [Published: 14 August 2018] Research abstract: … Continue reading

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Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/ chronic fatigue syndrome patients: A preliminary investigation, by Thao Nguyen, D Staines, S Johnston, S Marshall-Gradisnik in Asian Pac J Allergy Immunol. 2018 Jul 8. [Epub ahead of print] … Continue reading

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Association of T & NK cell phenotype with the diagnosis of ME/CFS

Research abstract: Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jose Luis Rivas, Teresa Palencia, Guerau Fernández, Milagros Garcia in Front. Immunol., 09 May 2018 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is … Continue reading

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Rituximab impedes natural killer cell function in CFS/ME patients

Research abstract: Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation by Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines and Sonya Marshall-Gradisnik in BMC Pharmacology and Toxicology 2018 19:12 [Published: … Continue reading

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CFS and the immune system

Review summary: Chronic fatigue syndrome and the immune system: Where are we now?, by Fane Kojo Fosu Mensaha, Amolak Singh Bansal, Brian Ford, Geraldine Cambridge in Neurophysiologie Clinique/Clinical Neurophysiology [Available online 12 April 2017] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterised by multiple … Continue reading

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Calcium mobilisation in natural killer cells & cell cytotoxicity in CFS/ME

Research abstract: Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+ ) cell signalling. Reduced TRPM3 has been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with … Continue reading

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Dysregulation of protein kinase gene expression in NK Cells in CFS

Research abstract: BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes … Continue reading

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