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Central pathways causing fatigue in CFS
Article abstract Background The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes. Many patients suffering from … Continue reading
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Tagged auto-immune, fatigue, neuro-inflammatory, oxidative stress, pro-inflammatory cytokines
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Vitamin D supplement doesn’t improve CFS/ME symptoms
Research abstract Highlights We randomised 50 patients with CFS/ME to receive six months of intermittent high-dose vitamin D or placebo. Vitamin D did not improve pulse-wave velocity or flow-mediated dilatation of the brachial artery compared to placebo. Vitamin D did … Continue reading
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Tagged arterial stiffness, cardiovascular function, fatigue, oxidative stress, Vitamin D
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Altered immune response to exercise in CFS/ME
Abstract An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing … Continue reading
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Tagged exercise, gene expression, immune system, J Nijs, oxidative stress
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Multivitamin mineral supplementation helpful in CFS
Abstract Background Chronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and … Continue reading
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Tagged multivitamins, oxidative stress, SOD, supplements, vitamins
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Possible causes of mitochondrial dysfunctions in ME
Abstract Myalgic encephalomyelitis / chronic fatigue syndrome (ME/cfs) is classified by the World Health Organization as a disorder of the central nervous system. ME/cfs is an neuro-immune disorder accompanied by chronic low-grade inflammation, increased levels of oxidative and nitrosative stress … Continue reading
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Tagged Gerwyn Morris, immuno-flammatory pathway, Michael Maes, mitochondrial dysfunction, nitrosative stress, oxidative stress
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Mitochondrial dysfunction differs in CFS and FM
Research abstract Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are complex and serious illnesses that affect approximately 2.5% and 5% of the general population worldwide, respectively. The etiology is unknown; however, recent studies suggest that mitochondrial dysfunction has been involved … Continue reading
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Tagged Fibromyalgia, FM, mitochondrial dysfunction, oxidative stress
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Oxidative stress and possible early signs of atherosclerosis in CFS
The abstract of a Serbian study: INTRODUCTION: Chronic fatigue syndrome (CFS) is a widely recognized problem, characterized by prolonged, debilitating fatigue and a characteristic group of accompanying symptoms, that occurs four times more frequently in women than in men. The … Continue reading
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Tagged antioxidant treatment, atherosclerosis, lipid profile, oxidative stress
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