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Illness progression in CFS: immune signature changes
Research abstract: Background: Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to explore the shift in discriminatory cytokines across ME/CFS subjects … Continue reading
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Tagged biomarkers, cytokines, Dr Nancy Klimas, immune profile
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Altered immunity found in Q fever fatigue syndrome
Research Highlights: We explored the specific IFNγ production, and the IFNγ/IL-2 ratio in QFS patients. QFS patients have a significant higher IFNγ production than seropositive controls. The IFNγ/IL-2 ratio is significantly lower in QFS than in chronic Q-fever patients. These … Continue reading
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Tagged cell mediated immunity, coxiella burnetii, cytokines, Q fever fatigue syndrome, QFS
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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid
Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading
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Tagged C.G. Gottschalk, Central Nervous System, cerebrospinal fluid, CNS, cytokines, Dr Daniel Peterson, immune activation, Prof Ian Lipkin, Prof Mady Hornig
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Abnormal cytokine/chemokine profile in ME/CFS is associated with clinical symptoms
Research highlights: Abnormal cytokine/chemokine profile in ME/CFS associated with clinical symptoms. A cluster of IL-16, IL-7 and VEGF-A that may suggests neuro-inflammation as the pathogenesis mechanism in ME/CFS. Potential diagnostic biomarkers proven by vigorous mathematical/statistical analysis. Abstract: Recently, differences in … Continue reading
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Tagged chemokines, cytokines, Dr Suzanne Vernon, interleukins, neuro-inflammatory, Vascular Endothelial Growth Factor A, VEGF-A
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A comparison of cytokine profiles of CFS/ME and MS patients
Research abstract: Background: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME), is a debilitating condition that presents with a range of symptoms, including fatigue, cognitive dysfunction, muscular and joint pain, and may be immune-mediated. In particular, patients exhibit abnormal … Continue reading
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Tagged cytokines, immune system dysfunction, MS, Multiple Sclerosis
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Dr Jarred Younger interview about his neuroinflammation research
Cort Johnson interviews Dr Jarred Younger, head of the Neuroinflammation, Pain and Fatigue Lab at the University of Alabama at Birmingham about the neuroinflammation response in ME/CFS and FM, how to measure it and the types of anti-inflammatory drugs that … Continue reading
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Tagged Cort Johnson, cytokines, Dr Jarred Younger, fatigue, Fibromyalgia, FM, LDN, low dose naltrexone, lymphatic network, microglia, Neuroinflammation, pain
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CFS subgroup found to have low level inflammation
CFS is characterized by profound levels of persistent/recurrent fatigue. It is proposed that chronic, low level inflammation may play a role in this fatigue. We recruited 100 untreated patients with CFS (average age 33±12) and 100 age and sex matched … Continue reading
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Tagged cytokines, inflammation, mitochondrial dysfunction, muscle fatigue
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Central nervous system clues found for cognitive dysfunction in CFS
Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading
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Tagged autoimmune, cerebrospinal fluid, cognitive dysfunction, cytokines, Dr Daniel Peterson, immune activation, Prof Ian Lipkin, Prof Maddy Hornig
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Could toll-like receptors be a new therapeutic approach for ME?
Article abstract Perturbations in immune processes play an important role in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), a multifactorial disorder mainly characterized by severe and prolonged fatigue and typically affecting a variety of bodily systems including the immune system. Recent reports … Continue reading
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Tagged autonomic dysfunction, cytokines, Gut microbes, immunomodulators, inflammatory disorder, TLRs, toll-like receptors
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Distinct stages found in ME/CFS
Research abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find … Continue reading
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Tagged BBC, Columbia University, Cort Johnson, cytokines, Prof Maddy Hornig
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