Tag Archives: Dr Oystein Fluge

Metabolic profiling indicates impaired pyruvate dehydrogenase function in ME/CFS

Research abstract: Myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) is a debilitating disease of unknown etiology, with hallmark symptoms including postexertional malaise and poor recovery. Metabolic dysfunction is a plausible contributing factor. We hypothesized that changes in serum amino acids may disclose … Continue reading

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The RituxME & CycloME studies – video of Dr Oystein Fluge talk

Video posted on the RME Sverige You Tube channel, 19 Nov 2016: The RituxME and CycloME studies – Ongoing Clinical Research in the ME/CFS Research Group, by Öystein Fluge, MD, Dep. Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norge … Continue reading

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Mella finds hypometabolic state in ME/CFS

Health rising blog post, by Cort Johnson, 15 October 2016: Another Hypometabolic Signature Found Fluge and Mella are best known for their Rituximab work, but just last week Mella reported that they’d found a hypometabolic state in ME/CFS as well. … Continue reading

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New rituximab trial results from Norway

Research abstract: Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We have previously suggested clinical benefit from B-cell depletion using the monoclonal anti-CD20 antibody rituximab in a randomized and placebo-controlled study. Prolonged responses were then demonstrated in … Continue reading

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Cancer doctor Dagfinn Øgreid has treated ME patients with rituximab

Blog article: Offers private ME treatment with cancer drugs – scientists react, by Anne Grete Storvik, Nov 23 2015 in Dagensmedicin [ translated by Google translate] A private clinic in Sandnes offers treatment for ME with the cancer drug rituximab. Patients pay … Continue reading

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UK rituximab trial fundraising total almost reached

Invest in ME has announced the latest fundraising total for the rituximab/B-cell research, which is a great boost as the research team at UCL are about to visit and discuss the subject with Dr Fluge and Professor Mella in Haukeland University Hospital, … Continue reading

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Elevated autoantibodies found in CFS subgroup

Research highlights: β adrenergic and muscarinic acetylcholine receptor autoantibodies are elevated in a subset of patients with Chronic Fatigue Syndrome (CFS). Elevated autoantibodies in CFS correlate with elevated IgG1-3 subclass levels, thyreoperoxidase and ANA antibodies and T cell activation. In … Continue reading

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Rituximab leads to B-cell depletion and remission in ME/CFS

Research abstract: Background: Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti-CD20 antibody rituximab … Continue reading

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Fluge & Mella’s patent application for a CFS treatment

Excerpt from patent application: Inventors: Øystein Fluge & Olav Mella Date of publication 26 11 2014 Nitric oxide donor for the treatment of chronic fatigue syndrome. Description [0001] The present invention relates in a first aspect to a nitric oxide donor for … Continue reading

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Rituximab interviews

Two Norwegian scientists, Øystein Fluge and Olav Mella, who have been researching the effects of an anti-lymphoma drug called Rituximab on people with ME/CFS, talked about their work on the BBC Radio Cambridgeshire programme ‘Naked Scientists’ on Sunday, 22 March. … Continue reading

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