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Latest News
- Hypothesis: Broken connections: the evidence for neuroglial failure in ME/CFS
- Research review: The enterovirus theory of disease etiology in ME/CFS
- NICE delays Roundtable – no invite for WAMES!
- Genetic research: Fine mapping of the major histocompatibility complex (MHC) in ME/CFS
- Research: A map of metabolic phenotypes in patients with ME/CFS
Archives
Tag Archives: DNA methylation
Research: The SARS-CoV-2 receptor ACE2 in ME/CFS
The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a meta-analysis of public DNA methylation and gene expression data, by João Malato, Franziska Sotzny, Sandra Bauer, Helma Freitag, André Fonseca, Anna D Grabowska, Luís Graça, Clara Cordeiro, … Continue reading
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Tagged ACE2, André Fonseca, Anna D Grabowska, Carmen Scheibenbogen, Clara Cordeiro, COVID-19, DNA methylation, Dr Luis Nacul, Eliana M Lacerda, Francisco Westermeier, Franziska Sotzny, gene expression, Helma Freitag, Jesús Castro-Marrero, João Malato, Luís Graça, Nuno Sepulveda, Sandra Bauer, SARS-CoV-2
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Changes in DNA methylation profiles of ME/CFS patients reflect systemic dysfunctions
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions, by AM Helliwell, EC Sweetman, PA Stockwell, CD Edgar, A Chatterjee & WP Tate in Clinical Epigenetics vol 12, no: 167 (2020) Research abstract: Background: … Continue reading
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Tagged A Chatterjee, Amber Helliwell, Christina Edgar, DNA methylation, Eiren Sweetman, PA Stockwell, PBMC, peripheral blood mononuclear cells, Prof Warren Tate, reduced representation bisulphite sequencing, RRBS
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Genome-epigenome interactions associated with ME/CFS
Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon and Patrick O McGowan in Epigenetics 2018 [Published online: 5 Dec 2018] Research abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) … Continue reading
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Tagged David Ashbrook, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, genotypes, Santiago Herrera, Wilfred C de Vega
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Integration of DNA methylation & health scores identifies subtypes in ME/CFS
Research abstract: Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome, by Wilfred C de Vega, Lauren Erdman, Suzanne D Vernon, Anna Goldenberg & Patrick O McGowan in Epigenomics. 2018 Apr 25. doi: 10.2217/epi-2017-0150. [Epub … Continue reading
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Tagged Anna Goldenberg, clinical subtyping, DePaul Symptom Questionnaire, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, Lauren Erdman, RAND-36 Short Form Survey, sub-groups, Wilfred C de Vega
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Genome-epigenome interactions associated with ME/CFS
Research abstract: Genome-Epigenome Interactions Associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon, Patrick O McGowan in Biorxiv [preprint 22 Dec 2017] Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an example of … Continue reading
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Tagged David Ashbrook, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenomics, genomics, Santiago Herrera, Wilfred C de Vega
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Epigenetic modifications & glucocorticoid sensitivity in ME/CFS
Research abstract: Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite … Continue reading
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Tagged DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, glucocorticoid sensitivity, HPA axis functioning, innune cells, Santiago Herrera, Wilfred C de Vega
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Changes to genes found in IBS
Research abstract: Background: Irritable bowel syndrome (IBS) is a stress-sensitive disorder. Environmental factors including stress can trigger epigenetic changes, which have not been well-studied in IBS. We performed a pilot study investigating genome-wide DNA methylation of IBS patients and healthy … Continue reading
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Tagged DNA methylation, epigenetics, gene modification, IBS, Irritable bowel syndrome, methylome
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Childhood trauma did not increase changes to DNA in women with CFS
Research abstract: OBJECTIVES: Chronic fatigue syndrome (CFS) has been associated with hypothalamic-pituitary-adrenal axis hypofunction and enhanced glucocorticoid receptor (GR) sensitivity. In addition, childhood trauma is considered a major risk factor for the syndrome. This study examines DNA methylation of the … Continue reading
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Tagged childhood trauma, DNA methylation, glucocorticoid receptor sensitivity, HPA axis hypofunction, hypothalamic-pituitary-adrenal axis hypofunction
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