Tag Archives: DNA methylation

Research: The SARS-CoV-2 receptor ACE2 in ME/CFS

Posted on 09/08/2021 by wames

The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in  Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a meta-analysis of public DNA methylation and gene expression data, by João Malato, Franziska Sotzny, Sandra Bauer, Helma Freitag, André Fonseca, Anna D Grabowska, Luís Graça, Clara Cordeiro, … Continue reading →

Posted in News | Tagged , , , , , , , , , , , , , , , , , , | Comments Off on Research: The SARS-CoV-2 receptor ACE2 in ME/CFS

Recursive ensemble feature selection provides a robust mRNA expression signature for ME/CFS

Posted on 03/04/2021 by wames

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome, by Paula I Metselaar, Lucero Mendoza-Maldonado, Andrew Yung Fong Li Yim, Ilias Abarkan, Peter Henneman, Anje A Te Velde, Alexander Schönhuth, Jos A Bosch, Aletta … Continue reading →

Posted in News | Tagged , , , , , , , , , , , , , , , , | Comments Off on Recursive ensemble feature selection provides a robust mRNA expression signature for ME/CFS

Changes in DNA methylation profiles of ME/CFS patients reflect systemic dysfunctions

Posted on 11/27/2020 by wames

Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions, by AM Helliwell, EC Sweetman, PA Stockwell, CD Edgar, A Chatterjee & WP Tate in Clinical Epigenetics vol 12, no: 167 (2020)   Research abstract: Background: … Continue reading →

Posted in News | Tagged , , , , , , , , , , | Comments Off on Changes in DNA methylation profiles of ME/CFS patients reflect systemic dysfunctions

Genome-epigenome interactions associated with ME/CFS

Posted on 01/18/2019 by wames

Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon and Patrick O McGowan in Epigenetics 2018 [Published online: 5 Dec 2018]   Research abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) … Continue reading →

Posted in News | Tagged , , , , , , , | Comments Off on Genome-epigenome interactions associated with ME/CFS

Integration of DNA methylation & health scores identifies subtypes in ME/CFS

Posted on 04/30/2018 by wames

Research abstract: Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome, by Wilfred C de Vega, Lauren Erdman, Suzanne D Vernon, Anna Goldenberg & Patrick O McGowan in Epigenomics. 2018 Apr 25. doi: 10.2217/epi-2017-0150. [Epub … Continue reading →

Posted in News | Tagged , , , , , , , , , , | Comments Off on Integration of DNA methylation & health scores identifies subtypes in ME/CFS

Genome-epigenome interactions associated with ME/CFS

Posted on 01/23/2018 by wames

Research abstract: Genome-Epigenome Interactions Associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon, Patrick O McGowan in Biorxiv [preprint 22 Dec 2017] Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an example of … Continue reading →

Posted in News | Tagged , , , , , , , | Comments Off on Genome-epigenome interactions associated with ME/CFS

Epigenetic modifications & glucocorticoid sensitivity in ME/CFS

Posted on 02/28/2017 by wames

Research abstract: Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite … Continue reading →

Posted in News | Tagged , , , , , , , , | Comments Off on Epigenetic modifications & glucocorticoid sensitivity in ME/CFS

Changes to genes found in IBS

Posted on 01/15/2016 by wames

Research abstract: Background: Irritable bowel syndrome (IBS) is a stress-sensitive disorder. Environmental factors including stress can trigger epigenetic changes, which have not been well-studied in IBS. We performed a pilot study investigating genome-wide DNA methylation of IBS patients and healthy … Continue reading →

Posted in News | Tagged , , , , , | Comments Off on Changes to genes found in IBS

Childhood trauma did not increase changes to DNA in women with CFS

Posted on 09/10/2015 by wames

Research abstract: OBJECTIVES: Chronic fatigue syndrome (CFS) has been associated with hypothalamic-pituitary-adrenal axis hypofunction and enhanced glucocorticoid receptor (GR) sensitivity. In addition, childhood trauma is considered a major risk factor for the syndrome. This study examines DNA methylation of the … Continue reading →

Posted in News | Tagged , , , , | Comments Off on Childhood trauma did not increase changes to DNA in women with CFS