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Latest News
- Dysregulated provision of oxidisable substrates to the mitochondria in ME/CFS lymphoblasts
- Sex-based differences in plasma autoantibodies to CNS proteins in Gulf War veterans versus healthy & symptomatic controls
- Sick of the sick role: narratives of what ‘recovery’ means to people with CFS/ME
- Plasma proteomics publication shows disrupted cell-to-cell signaling in ME/CFS
- Open‐label study with the monoamine stabilizer (‐)‐OSU6162 [drug] in ME/CFS
Archives
Tag Archives: DNA methylation
Changes in DNA methylation profiles of ME/CFS patients reflect systemic dysfunctions
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions, by AM Helliwell, EC Sweetman, PA Stockwell, CD Edgar, A Chatterjee & WP Tate in Clinical Epigenetics vol 12, no: 167 (2020) Research abstract: Background: … Continue reading
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Tagged A Chatterjee, Amber Helliwell, Christina Edgar, DNA methylation, Eiren Sweetman, PA Stockwell, PBMC, peripheral blood mononuclear cells, Prof Warren Tate, reduced representation bisulphite sequencing, RRBS
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Genome-epigenome interactions associated with ME/CFS
Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon and Patrick O McGowan in Epigenetics 2018 [Published online: 5 Dec 2018] Research abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) … Continue reading
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Tagged David Ashbrook, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, genotypes, Santiago Herrera, Wilfred C de Vega
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Integration of DNA methylation & health scores identifies subtypes in ME/CFS
Research abstract: Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome, by Wilfred C de Vega, Lauren Erdman, Suzanne D Vernon, Anna Goldenberg & Patrick O McGowan in Epigenomics. 2018 Apr 25. doi: 10.2217/epi-2017-0150. [Epub … Continue reading
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Tagged Anna Goldenberg, clinical subtyping, DePaul Symptom Questionnaire, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, Lauren Erdman, RAND-36 Short Form Survey, sub-groups, Wilfred C de Vega
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Genome-epigenome interactions associated with ME/CFS
Research abstract: Genome-Epigenome Interactions Associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Santiago Herrera, Wilfred C de Vega, David Ashbrook, Suzanne D Vernon, Patrick O McGowan in Biorxiv [preprint 22 Dec 2017] Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an example of … Continue reading
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Tagged David Ashbrook, DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenomics, genomics, Santiago Herrera, Wilfred C de Vega
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Epigenetic modifications & glucocorticoid sensitivity in ME/CFS
Research abstract: Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite … Continue reading
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Tagged DNA methylation, Dr Patrick O McGowan, Dr Suzanne Vernon, epigenetics, glucocorticoid sensitivity, HPA axis functioning, innune cells, Santiago Herrera, Wilfred C de Vega
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Changes to genes found in IBS
Research abstract: Background: Irritable bowel syndrome (IBS) is a stress-sensitive disorder. Environmental factors including stress can trigger epigenetic changes, which have not been well-studied in IBS. We performed a pilot study investigating genome-wide DNA methylation of IBS patients and healthy … Continue reading
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Tagged DNA methylation, epigenetics, gene modification, IBS, Irritable bowel syndrome, methylome
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Childhood trauma did not increase changes to DNA in women with CFS
Research abstract: OBJECTIVES: Chronic fatigue syndrome (CFS) has been associated with hypothalamic-pituitary-adrenal axis hypofunction and enhanced glucocorticoid receptor (GR) sensitivity. In addition, childhood trauma is considered a major risk factor for the syndrome. This study examines DNA methylation of the … Continue reading
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Tagged childhood trauma, DNA methylation, glucocorticoid receptor sensitivity, HPA axis hypofunction, hypothalamic-pituitary-adrenal axis hypofunction
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