Tag Archives: SNPs

A systematic review of the association between fatigue & genetic polymorphisms

Review abstract: Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including … Continue reading

Posted in News | Tagged , , , , , , | Comments Off on A systematic review of the association between fatigue & genetic polymorphisms

A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors

Research abstract: BACKGROUND: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME) is a debilitating condition of unknown aetiology. It is characterized by a range of physiological effects including neurological, sensory and motor disturbances. This study examined candidate genes for … Continue reading

Posted in News | Tagged , , , , , | Comments Off on A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors

Natural killer cell & SNP dysfunction in ME/CFS

Research abstract: Aim: The aim of this paper was to determine natural killer (NK) cytotoxic activity and if single nucleotide polymorphisms (SNPs) and genotypes in transient receptor potential (TRP) ion channels and acetylcholine receptors (AChRs) were present in isolated NK … Continue reading

Posted in News | Tagged , , , , | Comments Off on Natural killer cell & SNP dysfunction in ME/CFS

The search for a genetic predisposition to ME/CFS

ME Research article, 26 February 2016: Genome-wide associations In human beings, a very small number of DNA gene sequences differ between individuals, and these consist largely of single nucleotide polymorphisms (SNPs, pronounced “snips”). While most SNPs are silent, others have … Continue reading

Posted in News | Tagged , , , , | Comments Off on The search for a genetic predisposition to ME/CFS

Genetic risk prediction methods applied to CFS

Research abstract: Background: The current practice of using only a few strongly associated genetic markers in regression models results in generally low power in prediction or accounting for heritability of complex human traits. Purpose: We illustrate here a Bayesian joint … Continue reading

Posted in News | Tagged , | Comments Off on Genetic risk prediction methods applied to CFS

Genes disrupt signalling mechanisms in CFS

Research abstract: Background: The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles … Continue reading

Posted in News | Tagged , , , , | Comments Off on Genes disrupt signalling mechanisms in CFS

SNPs in CFS/ME genes could lead to diagnostic test for CFS/ME subtypes

Research abstract Aims We have reported gene expression changes in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and the fact that such gene expression data can be used to identify subtypes of CFS/ME with distinct clinical phenotypes. Due to the … Continue reading

Posted in News | Tagged , , , , , , | Comments Off on SNPs in CFS/ME genes could lead to diagnostic test for CFS/ME subtypes