Changes in circulating microRNA after recumbent isometric yoga practice by patients with ME/CFS

Posted on 01/22/2020 by wames

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study, by Shu Takakura, Takakazu Oka & Nobuyuki Sudo in BioPsychoSocial Medicine vol 13, no. 29 (Dec 2019)

 

Research abstract:

Background:
Yoga is a representative mind-body therapy. Our previous studies have demonstrated that isometric yoga (i.e. yoga programs that we developed so individuals can practice yoga poses with a self-adjustable isometric load) reduces the fatigue of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, the underlying mechanisms remain unclear. Several studies have suggested that the micro-ribonucleic acid (miRNA) expression of ME/CFS patients is different from that of healthy subjects. However, it has not to date been determined if the practice of isometric yoga can affect miRNA expression. Therefore, we sought to investigate if isometric yoga is associated with changes in the expression levels of serum miRNA of patients with ME/CFS.

Methods:
The study included nine patients with ME/CFS who failed to show satisfactory improvement after at least 6 months of treatment administered at our hospital. Patients practiced recumbent isometric yoga for 3 months; they met with a yoga instructor every 2 to 4 weeks and participated in daily in-home sessions. The effect of recumbent isometric yoga on fatigue was assessed by comparing pre- and post-intervention scores on the Japanese version of the 11-item Chalder fatigue scale (CFQ 11). Patient blood samples were drawn pre- and post-intervention, just prior to practicing recumbent isometric yoga with an instructor. The serum was used for miRNA array analysis with known human miRNAs.

Results:
The average CFQ 11 score decreased significantly (from 25.3 ± 5.5 to 17.0 ± 5.8, p <  0.0001) after practicing recumbent isometric yoga for 3 months. The miRNA microarray analysis revealed that four miRNAs were significantly upregulated, and 42 were downregulated after the intervention period.

Conclusions:
This explorative pilot study is the first to demonstrate changes in the serum levels of several miRNAs after regular practice of recumbent isometric yoga. These miRNAs might represent biomarkers for the fatigue-relieving effects of isometric yoga of patients with ME/CFS.

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The impact of a Structured Exercise Programme upon cognitive function in CFS patients

Posted on 01/21/2020 by wames

The impact of a structured exercise programme upon cognitive function in Chronic Fatigue Syndrome patients, by Paweł Zalewski, Sławomir Kujawski, Malwina Tudorowska, Karl Morten, Małgorzata Tafil-Klawe, Jacek J. Klawe, James Strong, Fernando Estevez-Lopez, Modra Murovska, Julia L. Newton and the European Network on ME/CFS (EUROMENE) in Brain Sciences Vol 10, #1, p 4, Dec 2019

 

Research abstract:

Background:
Cognitive function disturbance is a frequently described symptom of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). In this study, the effects of a structured exercise programme (SEP) upon cognitive function in ME/CFS patients was examined.

Methods:
Out of the 53 ME/CFS patients initiating SEP 34 (64%) completed the 16 week programme. Cognitive function was assessed using a computerized battery test consisting of a Simple Reaction Time (SRT) (repeated three times) and Choice Reaction Time (CRT) measurements, a Visual Attention Test (VAT) and a Delayed Matching to Sample (DMS) assessment.

Results:
Statistically significant improvement was noted in the third attempt to SRT in reaction time for correct answers, p=0.045, r=0.24. Moreover, significant improvement was noted in VAT reaction time, number of correct answers and errors committed, p=0.02, omega=0.03, p=0.007, r=0.34 and p=0.004, r=0.35, respectively. Non-significant changes were noted in other cognitive tests.

Conclusions:
A substantial number of participants were unwilling or unable to complete the exercise programme. ME/CFS patients able to complete the SEP showed improved visual attention both in terms of reaction time and correctness of responses and processing speed of simple visual stimuli.

Comment on Science4ME blog:

69 patients identified with Fukuda diagnosis, only 34 were able to complete C-PET and exercise program. No control group. A range of cognitive tests on the 34 showed some improvement in average performance after the activity program on a few of the tests relating to reaction time and accuracy, but the results were not significant when corrected for multiple comparisons. Despite this, the authors claim exercise is effective in improving cognitive function for some CFS patients.

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Low-dose naltrexone as a treatment for CFS

Posted on 01/21/2020 by wames

Low-dose naltrexone as a treatment for chronic fatigue syndrome, by Monica Jane Bolton, Bryan Paul Chapman, Harm Van Marwijk, in BMJ Case Reports, Vol 13, #1, January 6, 2020

 

Research abstract:

Naltrexone is used as an off-label treatment in low doses for several chronic immune-modulated disorders in many countries. Although only small-scale clinical trials have been performed, these suggest efficacy in several diseases including Crohn’s disease, fibromyalgia and Gulf War Illness. Despite numerous internet reports of response to low-dose naltrexone (LDN), no clinical trials exist in people with chronic fatigue syndrome.

This condition is characterised by chronic profound fatigue, postexertional malaise, pain and autonomic and neurocognitive disturbances.

This series of three case reports compiled by people with long-term ill-health due to chronic fatigue syndrome shows the range of responses they observed when taking LDN, from life changing to a reduction in some symptoms only. Treatment doses ranged from 4 to 12 mg.

Clinical trials may be warranted to explore the potential use of naltrexone in people with these debilitating illnesses which currently have no licensed treatments available.

From discussion:

The mechanism of action for naltrexone at low dose in this disease group is unknown. It is possibly due to rebound of endorphins following short-term suppression or to direct action suppressing inflammation induced by microglia.39–41 There have been no formal dosing studies of naltrexone at low dose in any disorder. Therefore, although the dose of 3–4.5 mg is established in clinical practice, some practitioners use 9 mg (Klimas, personal communication, 2017) or higher(42) in chronic fatigue syndrome. Causality and dosing need further study.

…Internet reports suggest side effects can be troublesome initially, particularly increased fatigue and headaches.44 Two double-blind, placebo-controlled studies in people with fibromyalgia found no difference in tolerability between LDN and placebo but an increased frequency of vivid dreams and headaches.27 28 Recent work in Norway has found that individuals may experience fewer side effects if starting naltrexone at 6 mg, even if the final dose taken is lower than this (personal communication Brian Haviland 2018).

Patients’ perspective

Case 2
After 25 years of living with the devastating effects of myalgic encephalomyelitis, I was struggling to cope with the limited options for symptom and pain management. Having had many bad reactions to medications, I was hesitant to try a medication that would affect my immune system so I started out at an extremely low dose and slowly increased dosage. While the dreaming was at times disturbing, the positive changes gave me a hope for improvement I had not had in many years. The subsequent improvements have led to a much higher quality of life and I would like to see this medication as an approved option for others in my situation.

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A cross-national comparison of ME & CFS at tertiary care settings from the US & Spain

Posted on 01/20/2020 by wames

A Cross-National Comparison of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome at Tertiary Care Settings from the US and Spain, by Shaun Bhatia, Nicole Olczyk, Leonard A. Jason, Jose Alegre, Judith Fuentes-Llanos, Jesus Castro-Marrero in American Journal of Social Sciences and Humanities Vol. 5, No. 1, 104-115, 2020

 

Highlights of this paper:

  • Cross-cultural comparative studies serve as exemplars highlighting the challenges associated with assessing differences in symptoms, functional limitations, and work disability when using variant case definitions for ME and CFS. 
  • Using a single case definition, differences were observed on an array of symptoms and functional impairments from individuals with ME and CFS recruited at tertiary centers from the US and Spain. 
  • Disparity in ME and CFS symptomatology and impairment between the US and Spain may be attributed to differences in disability policy, perception of ME and CFS, and access to specialist care.

Research abstract:

Cross-national comparative studies are useful for describing the unique characteristics of complex illnesses, and can reveal culture-specific traits of disease frequency/severity and healthcare. Though myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are debilitating conditions found all over the world, few studies have examined their characteristics across different countries. T

he purpose of this study was to compare the levels of functional impairment and symptomatology in patients with ME and CFS at tertiary referral hospitals in the US and Spain.

Four hundred twenty potentially eligible participants (N = 235 from the US and N = 185 from Spain) who met the 1994 Fukuda et al. definition for CFS were enrolled. Both samples completed the medical outcomes study 36-item short-form health survey (SF-36) as a proxy for impairment, and the DePaul Symptom Questionnaire (DSQ) for patient symptomatology. ANCOVA and, where appropriate, MANCOVA tests were used to compare the SF-36 and DSQ items for illness characteristics between the samples.

The patients from Spain demonstrated significantly worse functioning than those from the US in the SF-36 domains of physical functioning, bodily pain, general health functioning, role emotional, and mental health functioning. The Spanish sample also was also more symptomatic across all the DSQ-items, most significantly in the pain and neuroendocrine domains.

These findings may be due to differences between the US and Spain regarding disability policy, perception of ME and CFS, and access to specialist care.

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Reduced heart rate variability predicts fatigue severity in individuals with CFS/ME

Posted on 01/16/2020 by wames

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis, by Rosa María Escorihuela, Lluís Capdevila, Juan Ramos Castro, María Cleofé Zaragozà, Sara Maurel, José Alegre & Jesús Castro-Marrero in Journal of Translational Medicine volume 18, Article number: 4 (2020)

 

Abstract:

Background:
Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME.

Methods:
In this case–control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded.

Results:
CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0.001), decreased RR intervals (p < 0.01), and decreased HRV time- and frequency-domain parameters (p < 0.005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0.005), RMSSD (p = 0.0268) and HFnu indices (p = 0.0067) in CFS/ME patients, but not in healthy controls.

Conclusions:
Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted.

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Recovering from CFS as an intra-active process

Posted on 01/15/2020 by wames

Recovering from chronic fatigue syndrome as an intra-active process, by Karen Synne Groven, Tone Dahl-Michelsen in Health Care Women International 12: 1-12, 2019

 

Abstract
In this article, we draw on the narrative of a woman who has recovered from chronic fatigue syndrome (CFS) to explore the process of recovering from a debilitating illness.

Inspired by Julia Kristeva’s notion of the body as a complex biocultural fact and by Karen Barad’s posthuman theory (also termed agential realism), we adopt an intra-active approach to the woman’s recovery process, revealing the role played by human as well as nonhuman entities.

In so doing, we move beyond “dualistic,” often polarized debates in the medical literature (and mainstream media) regarding the causes of CFS: debates in which “biological/ physiological” factors tend to be set against “mental/cognitive/psychological” ones. We argue for a medical perspective in which the intra-action of human and nonhuman agents is recognized as contributing to an individual’s recovery process.

Read full chapter

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A neuro-inflammatory model can explain the onset, symptoms and flare-ups of ME/CFS

Posted on 01/14/2020 by wames

A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome, by Angus Mackay in Journal of Primary Health Care 11(4) 300-307 2019 [https://doi.org/10.1071/HC19041]

 

Abstract:

A neuro-inflammatory model is proposed to explain the onset, symptoms and perpetuation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) via characteristic flare-ups (relapses).

In this article, I explore the proposition that a range of triggers (intense physiological stressors such as severe viral infections, chemical toxin exposure or emotional trauma) in ME/CFS-predisposed people causes disruption in the neural circuitry of the hypothalamus (paraventricular nucleus), which induces a neuro-inflammatory reaction in the brain and central nervous system of ME/CFS patients, via over-active innate immune (glial) cells.

Resulting dysfunction of the limbic system, the hypothalamus and consequently of the autonomic nervous system can then account for the diverse range of ME/CFS symptoms. Ongoing stressors feed into a compromised (inflamed) hypothalamus and if a certain (but variable) threshold is exceeded, a flare-up will ensue, inducing further ongoing neuro-inflammation in the central nervous system, thus perpetuating the disease indefinitely.

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Paediatric patients with ME/CFS value understanding & help to move on with their lives

Posted on 01/13/2020 by wames

Paediatric patients with myalgic encephalomyelitis/chronic fatigue syndrome value understanding and help to move on with their lives, by Katherine Rowe in Acta Paediatrica, First published: 18 December 2019 [https://doi.org/10.1111/apa.15054]

 

Abstract:

Aim:
The aim of this study was to document qualitative questionnaire feedback regarding management from a cohort observational study of young people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Methods:
Between 1991 and 2009, 784 paediatric patients, age 6‐18 years, were diagnosed with ME/CFS following referral to a specialised clinic at the Royal Children’s Hospital, Melbourne. Over a 14‐year period, feedback was requested on up to seven occasions.

Management included the following: symptom management and a self‐management lifestyle plan that included social, educational, physical and a pleasurable activity outside of home. They adjusted it by severity of illness, stage of education, family circumstances and life interests.

Results:
Questionnaires were returned from 626 (80%) with 44% providing feedback more than once. They reported that their management plan allowed them to regain control over their lives. They cited early diagnosis, empathetic, informed physicians, self‐management strategies and educational liaison as helping them to function and remain socially engaged. Ongoing support, particularly assistance to navigate the education system, was essential for general well‐being and ability to cope.

Conclusion:
Young people valued regaining the control over their lives that was lost through illness, support to maintain social contacts and assistance to achieve educational and/or life goals.

Key Notes:

  • A cohort observational study of 784 young people with myalgic encephalomyelitis/chronic fatigue syndrome provided feedback across a 14‐year period regarding helpful strategies and ways to improve management.
  • Early diagnosis, empathetic informed physicians, assistance with symptom control, self‐management strategies, educational liaison and advocacy enabled them to regain control, remain socially engaged and function optimally.
  • Doctors and teachers awareness of helpful strategies could significantly reduce distress with this illness.

Comment in Arch Dis Child 2020;105:451. doi:10.1136/archdischild-2020-319237

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The role of low-grade inflammation in ME/CFS – associations with symptoms

Posted on 01/13/2020 by wames

The role of low-grade inflammation in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) – associations with symptoms, by Martin A Jonsjö, Gunnar L Olsson, Rikard K Wicksell, Kjell Alving, Linda Holmström, Anna Andreasson in Psychoneuroendocrinology Vol 113, March 2020, 104578 [https://doi.org/10.1016/j.psyneuen.2019.104578]

 

Highlights

  • Associations between inflammatory markers and common symptoms in ME/CFS.
  • Higher levels of markers were significantly associated with higher levels of symptoms.
  • Biological sex moderated several associations.

Abstract

Background:
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often present with a range of flu-like symptoms resembling sickness behavior as well as widespread pain and concentration deficits. The aim of this study was to explore the association between inflammatory markers previously shown to be related to fatigue severity in ME/CFS and common ME/CFS symptoms post-exertional fatigue, impaired cognitive processing, musculoskeletal pain and recurrent flu-like symptoms, and the moderating effect of sex on these associations.

Methods:
53 adult patients diagnosed with ME/CFS at a specialist clinic were included in the study. Fasting blood plasma was analyzed using the Olink Proseek Multiplex Inflammation panel (β-NGF, CCL11, CXCL1, CXCL10, IL-6, IL-7, IL-8, IL-10, IL-18, TGF-α, TGF-β-1 and SCF) and BioRad Human Cytokine Type 1 assay (TNF-α). Participants rated the average severity of symptoms (0–10) based on the 2011 International Consensus Criteria of ME/CFS during a structured clinical interview. Associations between inflammatory markers and symptom severity were analyzed using bivariate correlations and moderated regression analyses bootstrapped with 5000 repetitions.

Results and conclusions:
Only β-NGF was associated with the fatigue severity measure. However, higher levels of CCL11, CXCL10, IL-7, TNF-α and TGF-β-1 were significantly associated with higher levels of impaired cognitive processing and musculoskeletal pain, and sex was a significant moderator for CXCL10, IL-7 and TGF-β-1. Future studies should investigate the relationship between inflammatory markers and key symptoms in ME/CFS in a longitudinal design in order to explore if and for whom low-grade inflammation may contribute to illness development.

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The All-Party Parliamentary Group on ME to re-convene – Please invite your MP to attend!

Posted on 01/09/2020 by wames

ME Association blog post: The All-Party Parliamentary Group on ME to Re-Convene – Please Invite Your MP to Attend! by Dr Charles Shepherd, 9 January 2020

 

 

Carol Monaghan MP has decided that the time is right to re-establish the APPG on ME.

Following the election, it was decided to hold an inaugural APPG meeting as soon as possible after members returned to Westminster, and this will now take place on Tuesday 14th January.

Invite Your MP to the Meeting

We now want people to contact their MPs, especially if they are known to be already interested in ME and invite them to attend.

FIND YOUR MP
For further information on the time and location of the meeting, your MP can contact Carol Monaghan via House of Commons email/telephone or consult the All-Party Notices.

More info on MEA website

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