Tag Archives: cytokines
Illness progression in CFS: immune signature changes
Research abstract: Background: Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to explore the shift in discriminatory cytokines across ME/CFS subjects … Continue reading
Altered immunity found in Q fever fatigue syndrome
Research Highlights: We explored the specific IFNγ production, and the IFNγ/IL-2 ratio in QFS patients. QFS patients have a significant higher IFNγ production than seropositive controls. The IFNγ/IL-2 ratio is significantly lower in QFS than in chronic Q-fever patients. These … Continue reading
Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid
Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading
Abnormal cytokine/chemokine profile in ME/CFS is associated with clinical symptoms
Research highlights: Abnormal cytokine/chemokine profile in ME/CFS associated with clinical symptoms. A cluster of IL-16, IL-7 and VEGF-A that may suggests neuro-inflammation as the pathogenesis mechanism in ME/CFS. Potential diagnostic biomarkers proven by vigorous mathematical/statistical analysis. Abstract: Recently, differences in … Continue reading
A comparison of cytokine profiles of CFS/ME and MS patients
Research abstract: Background: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME), is a debilitating condition that presents with a range of symptoms, including fatigue, cognitive dysfunction, muscular and joint pain, and may be immune-mediated. In particular, patients exhibit abnormal … Continue reading
CFS subgroup found to have low level inflammation
CFS is characterized by profound levels of persistent/recurrent fatigue. It is proposed that chronic, low level inflammation may play a role in this fatigue. We recruited 100 untreated patients with CFS (average age 33±12) and 100 age and sex matched … Continue reading
Central nervous system clues found for cognitive dysfunction in CFS
Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading
Could toll-like receptors be a new therapeutic approach for ME?
Article abstract Perturbations in immune processes play an important role in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), a multifactorial disorder mainly characterized by severe and prolonged fatigue and typically affecting a variety of bodily systems including the immune system. Recent reports … Continue reading
Distinct stages found in ME/CFS
Research abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find … Continue reading
Cytokine expression doesn’t reflect symptoms in adolsecent CFS
Highlights of Norwegian research Chronic fatigue syndrome (CFS) might be related to altered cytokine expression. A total of 120 adolescent CFS patients and 68 healthy controls were studied. Individual cytokine levels where similar across the two groups. Cytokine network parameters … Continue reading
