Tag Archives: Oxidative and nitrosative stress
Hypothesis: ME/CFS as an immune & oxidative stress disorder
The reification of the clinical diagnosis of myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as an immune and oxidative stress disorder: construction of a data-driven nomothethic network and exposure of ME/CFS subgroups, by Michael Maes, Marta Kubera, Kristina Stoyanova, Jean-Claude … Continue reading
Research review: Redox imbalance links COVID-19 & ME/CFS
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome, by Bindu D Paul, Marian D Lemle, Anthony L Komaroff, Solomon H Snyder in PNAS August 24, 2021 118 (34); [doi.org/10.1073/pnas.2024358118] Review abstract: Although most patients recover from acute COVID-19, … Continue reading
Theory: treatments for prolonged ICU patients may provide new therapeutic avenues for ME/CFS
Theory: treatments for prolonged ICU patients may provide new therapeutic veanues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), by Dominic Stanculescu, Lars Larsson and Jonas Bergquist in Front. Med. 7 May 2021 [doi.org/10.3389/fmed.2021.672370] Article abstract: We here provide an overview of … Continue reading
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, by Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri in Metabolic Brain Disease pp 1–31 [Online: 13 February Review article abstract: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), … Continue reading
Review of potential causes of muscle dysfunction in ME/CFS
Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading
Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS
Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading
The Toll-Like Receptor Radical Cycle Pathway – the key to drug treatment for secondary chronic fatigue
Review abstract: In this review we discuss that peripheral and central activation of the Toll-like receptor 2/4 (TLR2/4) Radical Cycle may underpin the pathophysiology of immune-related chronic fatigue secondary to other medical diseases and conditions. The TLR Radical Cycle plays … Continue reading
Physiological post-exertional abnormalities in ME & CFS
Review article extracts: Abstract: Post-exertional “malaise” is a hallmark symptom of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Various abnormalities, including abnormal physiological responses to exertion, can account for post-exertional “malaise” and “exercise avoidance”. Since these abnormalities are not … Continue reading
Neuro-immune pathophysiology of fatigue
Research abstract Many patients with systemic immune-inflammatory and neuro-inflammatory disorders, including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, cancer, cardiovascular disorder, Parkinson’s disease, multiple sclerosis, stroke, and chronic fatigue syndrome/myalgic encephalomyelitis, endure pathological levels of fatigue. The aim of … Continue reading
MS and ME similarities
Review abstract Background ‘Encephalomyelitis disseminata’ (multiple sclerosis) and myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) are both classified as diseases of the central nervous system by the World Health Organization. This review aims to compare the phenomenological and neuroimmune characteristics of … Continue reading
