Tag Archives: SNPs
Autoimmunity-related risk variants in PTPN22 & CTLA4 are associated with ME/CFS with infectious onset
Autoimmunity-related risk variants in PTPN22 and CTLA4 are associated with ME/CFS with infectious onset, by Sophie Steiner, Sonya C Becker, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Sandra Bauer, Madlen Löbel, Anna B Stittrich, Patricia Grabowski and Carmen Scheibenbogen in Front. Immunol., … Continue reading
A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors
Research abstract: BACKGROUND: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME) is a debilitating condition of unknown aetiology. It is characterized by a range of physiological effects including neurological, sensory and motor disturbances. This study examined candidate genes for … Continue reading
Natural killer cell & SNP dysfunction in ME/CFS
Research abstract: Aim: The aim of this paper was to determine natural killer (NK) cytotoxic activity and if single nucleotide polymorphisms (SNPs) and genotypes in transient receptor potential (TRP) ion channels and acetylcholine receptors (AChRs) were present in isolated NK … Continue reading
The search for a genetic predisposition to ME/CFS
ME Research article, 26 February 2016: Genome-wide associations In human beings, a very small number of DNA gene sequences differ between individuals, and these consist largely of single nucleotide polymorphisms (SNPs, pronounced “snips”). While most SNPs are silent, others have … Continue reading
Genetic risk prediction methods applied to CFS
Research abstract: Background: The current practice of using only a few strongly associated genetic markers in regression models results in generally low power in prediction or accounting for heritability of complex human traits. Purpose: We illustrate here a Bayesian joint … Continue reading
Genes disrupt signalling mechanisms in CFS
Research abstract: Background: The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles … Continue reading
SNPs in CFS/ME genes could lead to diagnostic test for CFS/ME subtypes
Research abstract Aims We have reported gene expression changes in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and the fact that such gene expression data can be used to identify subtypes of CFS/ME with distinct clinical phenotypes. Due to the … Continue reading
