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Hypothesis: ME/CFS as an immune & oxidative stress disorder
The reification of the clinical diagnosis of myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as an immune and oxidative stress disorder: construction of a data-driven nomothethic network and exposure of ME/CFS subgroups, by Michael Maes, Marta Kubera, Kristina Stoyanova, Jean-Claude … Continue reading
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Tagged bacterial translocation, depression, inflammation, Jean-Claude Leunis, Kristina Stoyanova, Marta Kubera, Michael Maes, Oxidative and nitrosative stress
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Mitochondria & immunity in CFS
Mitochondria and Immunity in Chronic Fatigue Syndrome, by G Anderson, Michael Maes in Prog Neuropsychopharmacol Biol Psychiatry 2020 May 26 [DOI:10.1016/j.pnpbp.2020.109976] Review abstract: It is widely accepted that the pathophysiology and treatment of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) … Continue reading
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Tagged blood immune cells, endogenous opioidergic system, George Anderson, gut microbiome, Michael Maes, mitochondria
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Environmental, neuro-immune & neuro-oxidative stress interactions in CFS
Environmental, neuro-immune, and neuro-oxidative stress interactions in Chronic Fatigue Syndrome, by Geir Bjørklund, Maryam Dadar, Lyudmila Pivina, Monica Daniela Doşa, Yuliya Semenova & Michael Maes in Molecular Neurobiology (2020) [doi.org/10.1007/s12035-020-01939-w] Review abstract: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS) is a complex, … Continue reading
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Tagged antioxidant treatment, environmental factors, Geir Bjørklund, immune-oxidative, immunological dysfunction, lipid replacement treatment, Lyudmila Pivina, Maryam Dadar, Michael Maes, Monica Daniela Doşa, oxidative stress, pathophysiology, Yuliya Semenova
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Is a diagnostic blood test for CFS on the horizon?
Is a diagnostic blood test for chronic fatigue syndrome on the horizon?, by Michael Maes, Laura Andres & Gerwyn Morris in Expert Review of Molecular Diagnostics, Published online: 18 Oct 2019 [https://doi.org/10.1080/14737159.2020.1681976] Expert opinion Most if not all biomarkers of … Continue reading
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Tagged biokmarkers, blood test, diagnostic test, Gerwyn Morris, Laura Andres, Michael Maes
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Shared microglial mechanisms underpinning depression & CFS & their comorbidities
Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities, by Adriano José Maia Chaves-Filho, Danielle S Macedo, David Freitas de Lucena, Michael Maes in Behavioural Brain Research Vol 372, 17 October 2019, 111975 [https://doi.org/10.1016/j.bbr.2019.111975] Research abstract: … Continue reading
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Tagged Adriano José Maia Chaves-Filho, cytokines, Danielle S Macedo, David Freitas de Lucena, depression, Michael Maes, microglia, neuro-immune dysregulation, oxidative stress
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ME/CFS: From pathophysiological insights to novel therapeutic opportunities
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: from pathophysiological insights to novel therapeutic opportunities, by Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk in Pharmacological Research [Available online 8 September 2019] https://doi.org/10.1016/j.phrs.2019.104450 … Continue reading
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Tagged Adam J Walker, Andre F Carvalho, Catherine Mazza, Coenzyme Q10, curcumin, Dr Basant K Puri, Gerwyn Morris, Ken Walder, melatonin, Michael Maes, molecular hydrogen, N-acetylcysteine, pharmaceutical therapy, Prof Michael Berk
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Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, by Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri in Metabolic Brain Disease pp 1–31 [Online: 13 February Review article abstract: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), … Continue reading
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Tagged Dr Basant K Puri, endotoxin tolerance, Gerwyn Morris, inflammation, Michael Maes, mitochondria, Oxidative and nitrosative stress, Prof Michael Berk
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Review of potential causes of muscle dysfunction in ME/CFS
Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading
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Tagged Gerwyn Morris, Michael Maes, mitochondrial dysfunction, muscle dysfunction, Oxidative and nitrosative stress
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Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS
Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading
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Tagged activated immune-inflammatory pathways, George Anderson, Gerwyn Morris, HPA axis hypofunction, hypothalamic-pituitary-adrenal axis hypofunction, Michael Maes, O&NS pathways, Oxidative and nitrosative stress
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A subset of ME/CFS patients have IBS
Research abstract: BACKGROUND: There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS: This study was carried out to examine … Continue reading
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Tagged abdominal discomfort syndrome, ADS, gastro-intestinal disorder, IBS, Irritable bowel syndrome, leaky gut, Michael Maes, subgroup
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