Tag Archives: Natural Killer cells

Loss of transient receptor potential Melastatin 3 ion channel function in natural killer cells from CFS/ME

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME patients by Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines and Sonya Marshall-Gradisnik in Molecular Medicine 2018 24:44 [Published: 14 August 2018] Research abstract: … Continue reading

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Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/ chronic fatigue syndrome patients: A preliminary investigation, by Thao Nguyen, D Staines, S Johnston, S Marshall-Gradisnik in Asian Pac J Allergy Immunol. 2018 Jul 8. [Epub ahead of print] … Continue reading

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Association of T & NK cell phenotype with the diagnosis of ME/CFS

Research abstract: Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jose Luis Rivas, Teresa Palencia, Guerau Fernández, Milagros Garcia in Front. Immunol., 09 May 2018 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is … Continue reading

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Rituximab impedes natural killer cell function in CFS/ME patients

Research abstract: Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation by Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines and Sonya Marshall-Gradisnik in BMC Pharmacology and Toxicology 2018 19:12 [Published: … Continue reading

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Longitudinal associations of lymphocyte subsets with clinical outcomes in CFS

Research abstract: Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome, by  Melissa L. Mehalick, Karen B. Schmaling , Daniel E. Sabath, & Dedra S. Buchwald in Fatigue: Biomedicine, Health & Behavior 2018 pp 1-12  [Published online: 12 Jan 2018] Background: … Continue reading

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Australian researchers discover abnormalities in immune cell receptors in ME/CFS

Huffington Post Australia, by Luke Cooper, 22 Feb 2017: Queensland Scientists Make Chronic Fatigue Syndrome Research Breakthrough The condition has been linked to abnormal immune system cells. Queensland scientists have linked Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis … Continue reading

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Calcium mobilisation in natural killer cells & cell cytotoxicity in CFS/ME

Research abstract: Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+ ) cell signalling. Reduced TRPM3 has been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with … Continue reading

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Dysregulation of protein kinase gene expression in NK Cells in CFS

Research abstract: BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes … Continue reading

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No difference found in difference in KIR expression in ME/CFS

Research abstract: Killer cell immunoglobulin-like receptor (KIR) genes encode for activating and inhibitory surface receptors, which are correlated with the regulation of Natural Killer (NK) cell cytotoxic activity. Reduced NK cell cytotoxic activity has been consistently reported in Chronic Fatigue … Continue reading

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Natural killer cell & SNP dysfunction in ME/CFS

Research abstract: Aim: The aim of this paper was to determine natural killer (NK) cytotoxic activity and if single nucleotide polymorphisms (SNPs) and genotypes in transient receptor potential (TRP) ion channels and acetylcholine receptors (AChRs) were present in isolated NK … Continue reading

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