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Bioenergetic & proteomic profiling of immune cells in ME/CFS patients
Bioenergetic and proteomic profiling of immune cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: an exploratory study, by Paula Fernandez-Guerra, Ana C Gonzalez-Ebsen, Susanne E Boonen, Julie Courraud, Niels Gregersen, Jesper Mehlsen, Johan Palmfeldt, Rikke K J Olsen, Louise Schouborg Brinth … Continue reading
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Tagged Ana C Gonzalez-Ebsen, extracellular flux analysis, Jesper Mehlsen, Johan Palmfeldt, Julie Courraud, Louise Schouborg Brinth, mitochondrial dysfunction, Niels Gregersen, Paula Fernandez-Guerra, PBMC, peripheral blood mononuclear cells, quantitative mass spectrometry-based proteomics, Rikke K J Olsen, Susanne E Boonen
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Impact of long-term cryopreservation on blood immune cell markers in ME/CFS: implications for biomarker discovery
Impact of long-term cryopreservation on blood immune cell markers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: implications for biomarker discovery, by Elisabet Gómez-Mora, Jorge Carrillo, Víctor Urrea, Josepa Rigau, José Alegre, Cecilia Cabrera, Elisa Oltra, Jesús Castro-Marrero and Julià Blanco in Front. … Continue reading
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Tagged Biobank, biomarkers, Cecilia Cabrera, cryopreservation, Elisabet Gómez-Mora, freezing, Jesús Castro-Marrero, José Alegre, Josepa Rigau, Julià Blanco, NK cells, PBMC, peripheral blood mononuclear cells, Prof Elisa Oltra, Víctor Urrea
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Changes in DNA methylation profiles of ME/CFS patients reflect systemic dysfunctions
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions, by AM Helliwell, EC Sweetman, PA Stockwell, CD Edgar, A Chatterjee & WP Tate in Clinical Epigenetics vol 12, no: 167 (2020) Research abstract: Background: … Continue reading
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Tagged A Chatterjee, Amber Helliwell, Christina Edgar, DNA methylation, Eiren Sweetman, PA Stockwell, PBMC, peripheral blood mononuclear cells, Prof Warren Tate, reduced representation bisulphite sequencing, RRBS
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A SWATH-MS analysis of ME/CFS peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction
A SWATH-MS analysis of ME/CFS peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction, by Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings & Warren Tate in Journal of Translational Medicine vol 18, no: 365 (2020) [doi.org/10.1186/s12967-020-02533-3] Research … Continue reading
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Tagged Adenosine triphosphate, ATP profile test, Christina Edgar, Dr Rosamund Vallings, Eiren Sweetman, Michel de Lange, mitochondrial dysfunction, PBMC, peripheral blood mononuclear cells, Prof Warren Tate, Torsten Kleffmann
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Unravelling ME/CFS: Gender‐specific changes in the microRNA expression profiling in ME/CFS
Unravelling ME/CFS: Gender‐specific changes in the microRNA expression profiling in ME/CFS by Amanpreet K Cheema, Leonor Sarria, Mina Bekheit, Fanny Collado, Eloy Almenar‐Pérez, Eva Martín‐Martínez, Jose Alegre, Jesus Castro‐Marrero, Mary A Fletcher, Nancy G Klimas, Elisa Oltra, Lubov Nathanson in … Continue reading
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Tagged Amanpreet K Cheema, Dr Nancy Klimas, Eloy Almenar‐Pérez, Eva Martín‐Martínez, exercise tests, Fanny Collado, Jesus Castro‐Marrero, José Alegre, Jose Alegre-Martin, Leonor Sarria, Lubov Nathanson, Mary Ann Fletcher, microRNAs, Mina Bekheit, miRNAs, PBMC, peripheral blood mononuclear cells, Prof Elisa Oltra
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The effect of ME/CFS severity on cellular bioenergetic function
The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function, by Cara Tomas, Joanna L Elson, Victoria Strassheim, Julia L Newton, Mark Walker in PLoS One vol 15, #4, e0231136, April 10, 2020 Research abstract: Myalgic … Continue reading
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Tagged bioenergetics, Cara Tomas, Dr Joanna Elson, glycolytic function, Mark Walker, mitochondrial dysfunction, PBMC, peripheral blood mononuclear cells, Prof Julia Newton, respiratory acidification, Victoria Strassheim
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Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells & extracellular vesicles in ME/CFS
Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Eloy Almenar-Pérez, Leonor Sarría, Lubov Nathanson & Elisa Oltra in Scientific Reports vol 10, no: 2064 (2020) Research abstract: Myalgic … Continue reading
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Tagged Creatine kinase, Eloy Almenar-Pérez, EVs, extracellular vesicles, Leonor Sarria, Lubov Nathanson, microRNA profiles, miRNomes, PBMC, peripheral blood mononuclear cells, Prof Elisa Oltra, severe ME
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An investigation into the modulation of T cell phenotypes by amitriptyline & nortriptyline
An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline, by JonathanRoyds, Melissa J Conroy, Margaret R Dunne, Connail McCrory, Joanne Lysaght in European Neuropsychopharmacology, Dec 2019[doi.org/10.1016/j.euroneuro.2019.12.106] Research abstract: Amitriptyline is prescribed for treating the symptoms … Continue reading
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Tagged amitriptyline, Connail McCrory, Joanne Lysaght, JonathanRoyds, killer T cells, Margaret R Dunne, Melissa J Conroy, Natural Killer cells, Neuroinflammation, neuropathic pain, Nortriptyline, PBMC, peripheral blood mononuclear cells
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Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test
Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test, by Cara Tomas, Tiffany A Lodge, Michelle Potter, Joanna L Elson, Julia L Newton, Karl J Morten, in Sci Rep. 2019 Aug 7;9(1):11464. doi: 10.1038/s41598-019-47966-z. Research abstract: The … Continue reading
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Tagged Cara Tomas, diagnostic test, Dr Joanna Elson, Dr Karl Morten, Dr Sarah Myhill, MES, Michelle Potter, Mitochondrial Energy Score, neutrophils, PBMC, peripheral blood mononuclear cells, Prof Julia Newton, Tiffany A Lodge
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