Search Results for: Sonya Marshall- Gradisnik
Immune dysfunction differs in moderate and severe CFS/ME over time
Research abstract: Background: Research has identified immunological abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), a heterogeneous illness with an unknown cause and absence of diagnostic test. There have been no CFS/ME studies examining innate and adaptive immune cells longitudinally in … Continue reading
Dysfunction found in innate and adaptive immune systems in CFS/ME
Research abstract: Background: Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The objective of this … Continue reading
Genes disrupt signalling mechanisms in CFS
Research abstract: Background: The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles … Continue reading
Serum cytokine levels vary in moderate and severe CFS/ME patients
Volume 70, Issue 1, November 2014, Pages 45 Research aims Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness with an unknown aetiology and diagnosis is based on symptom-specific criteria. Immunological dysregulation and cytokine abnormalities are consistent in CFS/ME. As … Continue reading
Reduced pro-inflammatory cytokines in the CSF of CFS/ME
Research abstract Objectives: Previous research has provided evidence for a dysregulation in cytokine levels in the periphery of patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date few studies have examined cytokines in the cerebrospinal fluid. The purpose of this … Continue reading
Methylation may have role in immunological changes in CFS/ME
Abstract Objective: Methylation is known to regulate biological processes and alterations in methylation patterns have been associated with a variety of diseases. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an unexplained disorder associated with immunological and molecular changes. CD4+T cells specifically, … Continue reading
9th Invest in ME International Conference report
A report has been produced by Rosamund Vallings MB BS of the Invest in ME 2014 conference held on 30th May. It includes a summary of the following sessions: Prof Jonathan Edwards (London) who spoke about the lessons learnt for ME … Continue reading
