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Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients
Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/ chronic fatigue syndrome patients: A preliminary investigation, by Thao Nguyen, D Staines, S Johnston, S Marshall-Gradisnik in Asian Pac J Allergy Immunol. 2018 Jul 8. [Epub ahead of print] … Continue reading
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Tagged ATP, Dr Samantha Johnston, Dr Sonya Marshall-Gradisnik, glycolitic reserve, Natural Killer cells, NK cells, Prof Donald Staines, T Nguyen
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Association of T & NK cell phenotype with the diagnosis of ME/CFS
Research abstract: Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jose Luis Rivas, Teresa Palencia, Guerau Fernández, Milagros Garcia in Front. Immunol., 09 May 2018 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is … Continue reading
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Tagged diagnosis, Guerau Fernández, immune dysfunction, immunological profile, Jose Luis Rivas, Milagros Garcia, Natural Killer cells, NK cells, T regulatory cells, Teresa Palencia
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Rituximab impedes natural killer cell function in CFS/ME patients
Research abstract: Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation by Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines and Sonya Marshall-Gradisnik in BMC Pharmacology and Toxicology 2018 19:12 [Published: … Continue reading
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Tagged Anne Klein, blood immune cells, Cassandra Balinas, Hélène Cabanas, Louise Durack, Natalie Eaton, Natural Killer cells, NK cells, Prof Donald Staines, rituximab, Sonya Marshall-Gradisnik
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Longitudinal associations of lymphocyte subsets with clinical outcomes in CFS
Research abstract: Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome, by Melissa L. Mehalick, Karen B. Schmaling , Daniel E. Sabath, & Dedra S. Buchwald in Fatigue: Biomedicine, Health & Behavior 2018 pp 1-12 [Published online: 12 Jan 2018] Background: … Continue reading
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Tagged Daniel E Sabath, Dedra S Buchwald, immune dysfyunction, Karen B Schmaling, lymphocytes, Melissa L Mehalick, Natural Killer cells, T-cell
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Australian researchers discover abnormalities in immune cell receptors in ME/CFS
Huffington Post Australia, by Luke Cooper, 22 Feb 2017: Queensland Scientists Make Chronic Fatigue Syndrome Research Breakthrough The condition has been linked to abnormal immune system cells. Queensland scientists have linked Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis … Continue reading
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Tagged Dr Samantha Johnston, Dr Sonja Marshall Gradisnik, Fiona McDonald, Huffington Post, immune cell receptors, impaired calcium mobilisation, L Clarke, Luke Cooper, Natural Killer cells, P Smith, Prof Donald Staines, Sciece alert, T Nguyen
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Calcium mobilisation in natural killer cells & cell cytotoxicity in CFS/ME
Research abstract: Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+ ) cell signalling. Reduced TRPM3 has been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with … Continue reading
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Tagged cell cytotoxicity, Dr Samantha Johnston, Dr Sonya Marshall-Gradisnik, L Clarke, Natural Killer cells, NK cells, P Smith, Prof Donald Staines, T Nguyen, TRPM3 genes
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Dysregulation of protein kinase gene expression in NK Cells in CFS
Research abstract: BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes … Continue reading
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Tagged Anu Chacko, Dr Samantha Johnston, Dr Sonja Marshall Gradisnik, Natural Killer cells, NK cells, Prof Donald Staines, protein kinase genes
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No difference found in difference in KIR expression in ME/CFS
Research abstract: Killer cell immunoglobulin-like receptor (KIR) genes encode for activating and inhibitory surface receptors, which are correlated with the regulation of Natural Killer (NK) cell cytotoxic activity. Reduced NK cell cytotoxic activity has been consistently reported in Chronic Fatigue … Continue reading
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Tagged Dr Sonya Marshall-Gradisnik, EW Brenu, KIR gene expression, Natural Killer cells, Prof Donald Staines, TK Huth
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Natural killer cell & SNP dysfunction in ME/CFS
Research abstract: Aim: The aim of this paper was to determine natural killer (NK) cytotoxic activity and if single nucleotide polymorphisms (SNPs) and genotypes in transient receptor potential (TRP) ion channels and acetylcholine receptors (AChRs) were present in isolated NK … Continue reading
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Tagged Dr Sonja Marshall Gradisnik, Natural Killer cells, NK cells, single nucleotide polymorphisms, SNPs
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Natural Killer Cells in CFS/ME & Multiple Sclerosis
Research abstract: Patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and multiple sclerosis (MS) suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue-related symptoms suffered by patients with CFS/ME and MS, dysfunction of the immune … Continue reading
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Tagged cytotoxic activity, immune system dysfunction, MS, Multiple Sclerosis, Natural Killer cells
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