Category Archives: News
IL-1 inhibition improves fatigue in CAPS
Research abstract: Cryopyrin associated periodic syndromes (CAPS) is a rare group of autoinflammatory disorders that includes familial cold autoinflammatory syndrome (FCAS), Muckle-wells syndrome (MWS), and Neonatal onset multisystemic inflammatory disease (NOMID) . CAPS is caused by a mutation in the … Continue reading
Immune and inflammation related genes in CFS
Research abstract: Recent evidence suggests immune and inflammatory alterations are important in chronic fatigue syndrome (CFS). This study was done to explore the association of functionally important genetic variants in inflammation and immune pathways with CFS. Peripheral blood DNA was … Continue reading
ME/CFS: a real illness
Comment on the US Institute of Medicine’s report and choice of new name SEID by Prof Anthony Komaroff: Chronic fatigue syndrome (named by some as myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS]) frustrates many physicians. That is understandable because there are no … Continue reading
Rituximab leads to B-cell depletion and remission in ME/CFS
Research abstract: Background: Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti-CD20 antibody rituximab … Continue reading
The need to list exclusionary illnesses for SEID
Research abstract: The Institute of Medicine recently proposed a new case definition for chronic fatigue syndrome (CFS), as well as a new name, Systemic Exertion Intolerance Disease (SEID). Contrary to the Fukuda et al.’s CFS case definition, there are few … Continue reading
Genetic risk prediction methods applied to CFS
Research abstract: Background: The current practice of using only a few strongly associated genetic markers in regression models results in generally low power in prediction or accounting for heritability of complex human traits. Purpose: We illustrate here a Bayesian joint … Continue reading
Mitochondrial depletion & energy problems in CFS
Mitochondrial Depletion Could Underlie the Energy Problems in Chronic Fatigue Syndrome, comment by Cort Johnson, May 26, 2015 Very, very few chronic fatigue syndrome studies have emerged from Germany, but the last two have been good ones. The one before this … Continue reading
Diagnostic methods for ME/CFS: a review
Research abstract: Background: The diagnosis of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is based on clinical criteria, yet there has been no consensus regarding which set of criteria best identifies patients with the condition. The Institute of Medicine has recently … Continue reading
Gene expression can differentiate CFS, FM and depression
Research abstract: OBJECTIVE To determine if independent candidate genes can be grouped into meaningful biological factors and if these factors are associated with the diagnosis of chronic fatigue syndrome (CFS) and fibromyalgia (FMS) while controlling for co-morbid depression, sex, and age. … Continue reading
