Category Archives: News

ME/CFS: a real illness

Comment on the US Institute of Medicine’s report and choice of new name SEID by Prof Anthony Komaroff: Chronic fatigue syndrome (named by some as myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS]) frustrates many physicians. That is understandable because there are no … Continue reading

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Rituximab leads to B-cell depletion and remission in ME/CFS

Research abstract: Background: Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti-CD20 antibody rituximab … Continue reading

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The need to list exclusionary illnesses for SEID

Research abstract: The Institute of Medicine recently proposed a new case definition for chronic fatigue syndrome (CFS), as well as a new name, Systemic Exertion Intolerance Disease (SEID). Contrary to the Fukuda et al.’s CFS case definition, there are few … Continue reading

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Genetic risk prediction methods applied to CFS

Research abstract: Background: The current practice of using only a few strongly associated genetic markers in regression models results in generally low power in prediction or accounting for heritability of complex human traits. Purpose: We illustrate here a Bayesian joint … Continue reading

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Mitochondrial depletion & energy problems in CFS

Mitochondrial Depletion Could Underlie the Energy Problems in Chronic Fatigue Syndrome, comment by Cort Johnson, May 26, 2015 Very, very few chronic  fatigue syndrome studies have emerged from Germany, but the last two have been good ones. The one before this … Continue reading

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Diagnostic methods for ME/CFS: a review

Research abstract: Background: The diagnosis of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is based on clinical criteria, yet there has been no consensus regarding which set of criteria best identifies patients with the condition. The Institute of Medicine has recently … Continue reading

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Gene expression can differentiate CFS, FM and depression

Research abstract: OBJECTIVE To determine if independent candidate genes can be grouped into meaningful biological factors and if these factors are associated with the diagnosis of chronic fatigue syndrome (CFS) and fibromyalgia (FMS) while controlling for co-morbid depression, sex, and age. … Continue reading

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The role of infections & moulds in chronic fatigue

Abstract Patients who present with severe intractable apparently idiopathic fatigue accompanied by profound physical and or cognitive disability present a significant therapeutic challenge. The effect of psychological counseling is limited, with significant but very slight improvements in psychometric measures of … Continue reading

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Fecal microbiota transplantation – a treatment in CFS?

Research abstract: Intestinal dysbiosis is now known to be a complication in a myriad of diseases. Fecal microbiota transplantation (FMT), as a microbiota-target therapy, is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal … Continue reading

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CFS v SEID as diagnostic criteria

Research abstract: Background: The Institute of Medicine has recommended a change in the name and criteria for chronic fatigue syndrome (CFS), renaming the illness systemic exertion intolerance disease (SEID). The new SEID case definition requires substantial reductions or impairments in … Continue reading

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