Tag Archives: CNS

Hypothesis: Broken connections: the evidence for neuroglial failure in ME/CFS

Posted on 09/22/2021 by wames

Broken Connections: The evidence for neuroglial failure in ME/CFS, by Herbert Renz-Polster, MD, Dorothee Bienzle, PhD 31 Aug 2021 [doi:10.31219/osf.io/ef3n4]   Review abstract: In spite of decades of research, the pathobiology of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is still … Continue reading →

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Sex-based differences in plasma autoantibodies to CNS proteins in Gulf War veterans versus healthy & symptomatic controls

Posted on 02/22/2021 by wames

Sex-based differences in plasma autoantibodies to Central Nervous System proteins in Gulf War veterans versus healthy and symptomatic controls, by Mohamed B Abou-Donia, Maxine H Krengel, Elizabeth S Lapadula, Clara G Zundel, Jessica LeClair, Joseph Massaro, Emily Quinn, Lisa A … Continue reading →

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Using plasma autoantibodies of Central Nervous System proteins to distinguish veterans with Gulf War Illness from healthy & symptomatic controls

Posted on 09/24/2020 by wames

Using plasma autoantibodies of Central Nervous System proteins to distinguish veterans with Gulf War Illness from healthy and symptomatic controls, by Mohamed B Abou-Donia, Elizabeth S Lapadula, Maxine H Krengel, Emily Quinn, Jessica LeClair, Joseph Massaro, Lisa A Conboy, Efi Kokkotou, … Continue reading →

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The putative glymphatic signature of CFS

Posted on 07/31/2018 by wames

The putative glymphatic signature of CFS: A new view on the disease pathogenesis and therapy, by Peter Wostyn, Peter Paul De Deyn in Medical Hypotheses Sept 2018, Vol 118, Pages 142–145 Abstract: The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there … Continue reading →

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Transient Receptor Potential Ion channels in the etiology & pathomechanism of CFS/ME

Posted on 05/30/2018 by wames

Research abstract: Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, by Donald Staines, S Du Preez, H Cabanas, C Balinas, N Eaton, R Passmore, R Maksoud, J Redmayne, S Marshall-Gradisnik in  International Journal … Continue reading →

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Inflammation correlates with symptoms in CFS

Posted on 08/18/2017 by wames

Research overview abstract: Inflammation correlates with symptoms in chronic fatigue syndrome, by Anthony L Komaroff in PNAS August 15, 2017 It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician … Continue reading →

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Central nervous system findings in CFS

Posted on 04/12/2017 by wames

Review abstract: CNS findings in chronic fatigue syndrome and a neuropathological case report Kimberly Ferrero, Mitchell Silver, Alan Cocchetto, Eliezer Masliah, Dianne Langford in Journal of Investigative Medicine Vol 65 Issue 4 [published 6 April 2017] Chronic fatigue syndrome (CFS) is characterized as a persistent, debilitating complex disorder of unknown … Continue reading →

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Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study

Posted on 08/16/2016 by wames

Research abstract: Background: A regulation system in the central nervous system plays an important role in controlling physical performance during physical fatigue. Purpose: To clarify the neural mechanisms of this regulation system during physical fatigue using magnetoencephalography (MEG) and a … Continue reading →

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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid

Posted on 01/26/2016 by wames

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading →

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Brain-derived neurotrophic factor concentration may not be depressed in CFS

Posted on 04/21/2015 by wames

Research abstract: Due to its effect on the central nervous system, brain-derived neurotrophic factor (BDNF) has been hypothesized to be involved in a number of neurodegenerative and psychiatric disorders. Recently, BDNF was also reported to be significantly lower in patients … Continue reading →

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