Tag Archives: cytokines
ME and Gulf War Illness have distinct immune profiles
Research abstract Highlights Gulf War illness (GWI) is characterized by a Th1/Th17 shift. Th1, Th2 and inflammatory cytokines characterize myalgic encephalomyelitis (ME). Cytokine importance by Random Forest were IL-7, IL-4, TNF-a, IL-13, and IL-17F. GWI and ME have distinct cytokine … Continue reading
Immune changes in peripheral blood in CFS
Book chapter abstract: Chronic Fatigue Syndrome (CFS) is recognized by the WHO as an alternative name for Myalgic Encephalomyelitis, which has been classified as a disease of the central nervous system since 1969. The concept that chronic microbial infection drives … Continue reading
Reduced pro-inflammatory cytokines in the CSF of CFS/ME
Research abstract Objectives: Previous research has provided evidence for a dysregulation in cytokine levels in the periphery of patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date few studies have examined cytokines in the cerebrospinal fluid. The purpose of this … Continue reading
Cytokine abnormalities in CFS
Research abstract We studied cytokine production in 15 patients with chronic fatigue syndrome (CFS) and 23 controls. CFS patients’ peripheral blood mononuclear cells were cultured with lipopolysaccharide or phytohemagglutinin. Enzymatic immunoassay indicated cytokine concentration in culture supernatants. CFS patients showed … Continue reading
Prolonged fatigue [CFS] & cytokines post-West Nile Virus infection in USA
Simon McGrath comments on a research paper: Evaluation of Prolonged Fatigue Post–West Nile Virus Infection and Association of Fatigue with Elevated Antiviral and Proinflammatory Cytokines Extract: 31% of the cohort were fatigued at follow-up (44/140) and “Of those with fatigue … Continue reading
Characterisation of impaired NK cells in CFS/ME
Abstract OBJECTIVE Natural Killer (NK) cells are classified into different phenotypes according to the expression of the surface markers CD56 and CD16. Each NK cell phenotype has a role in the immune response through cytotoxic activity or cytokine production. Reduced … Continue reading
Immune dysregulation in CFS similar to autoimmune disorders
Abstract Perturbations in immune processes are a hallmark of a number of autoimmune and inflammatory disorders. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is an inflammatory disorder with possible autoimmune correlates, characterized by reduced NK cell activity, elevations in regulatory T cells … Continue reading
Cytokines and neuropathic pain
Abstract Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems … Continue reading
Flu vaccination alters gene expression in CFS
Research abstract Vaccines have been shown to cause differential expression of genes and increase antibody titers against antigens. Influenza vaccines may have an effect on unexplained disorders such as Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Immunological changes have been identified following … Continue reading
Cytokine flucutations reflect fluctutations in fatigue severity
Research Abstract Background: Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent fatigue that is not alleviated by rest. The lack of a clearly identified underlying mechanism has hindered the development of effective treatments. Studies have demonstrated elevated … Continue reading
