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Research: Understanding the molecular changes of PEM in ME/CFS
Understanding the molecular changes of Post Exertional Malaise in ME/CFS, by Jemma Elley (Thesis, Bachelor of Biomedical Sciences with Honours). University of Otago, 2021 Research abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating and often life-long condition affecting … Continue reading
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Tagged 2-day exercise test, 8-hydroxy 2 deoxyguanosine, 8-OHdG, Adenosine triphosphate, ATP, DNA methylome, Jemma Elley, machine learning, mitochondrial dysfunction, oxidative stress, oxygen consumption, PEM, Post-exertional malaise, precision medicine, Prof Warren Tate
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Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients
Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/ chronic fatigue syndrome patients: A preliminary investigation, by Thao Nguyen, D Staines, S Johnston, S Marshall-Gradisnik in Asian Pac J Allergy Immunol. 2018 Jul 8. [Epub ahead of print] … Continue reading
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Tagged ATP, Dr Samantha Johnston, Dr Sonya Marshall-Gradisnik, glycolitic reserve, Natural Killer cells, NK cells, Prof Donald Staines, T Nguyen
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Is mitochondrial function abnormal in ME/CFS?
ME Research UK article, 12 January 2017: Is mitochondrial function abnormal? Mitochondria are often referred to as the power plants of the body because they are responsible for generating nearly all the energy needed to support life. These kidney bean-shaped … Continue reading
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Tagged Adenosine triphosphate, ATP, mitochondria, Nick Lawson
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Elevated energy production by non-mitochondrial sources in CFS sub-group
Research abstract: Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in … Continue reading
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Tagged ATP, Chung-Han Hsieh, Dana March, glycolysis, mitochondrial dysfunction, Nick Lawson, sub-groups, Xinnan Wang
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TRYCATS in CFS, Alzheimer’s disease and schizophrenia
Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading
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Tagged ATP, Gerwyn Morris, kynurenic acid, Michael Maes, neuro-immune illness, NMDA antagonists, pro-inflammatory cytokines, TRYCAT, tryptophan catabolites
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Computer simulation explores cause for exercise intolerance in ME/CFS
Research abstract: Post-exertional malaise is commonly observed in patients with myalgic encephalomyelitis/chronic fatigue syndrome, but its mechanism is not yet well understood. A reduced capacity for mitochondrial ATP synthesis is associated with the pathogenesis of CFS and is suspected to … Continue reading
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Tagged ATP, computer simulation, exercise intolerance, mitochondria, Post-exertional malaise
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Mitochondrial dysfunction and fatigue review
Abstract Fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after physical activity. Etiologic mechanisms underlying fatigue are not well understood; however, fatigue is a hallmark symptom of mitochondrial … Continue reading
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Tagged ATP, carnitine, Coenzyme Q10, fatigue, mitochondrial dysfunction
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Dr Myhill’s protocol improves mitochondrial function and fatigue
The third in a series of studies on mitochondrial function in ME/CFS has been published. Having established in the first two papers that mitochondrial dysfunction is a central pathophysiological lesion in ME/CFS, the aim of the third study was to … Continue reading
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Tagged ATP, Dr Sarah Myhill, John McLaren Howard, mitochondrial dysfunction, Norman E Booth
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