Tag Archives: ATP

Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/ chronic fatigue syndrome patients: A preliminary investigation, by Thao Nguyen, D Staines, S Johnston, S Marshall-Gradisnik in Asian Pac J Allergy Immunol. 2018 Jul 8. [Epub ahead of print] … Continue reading

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The Stanford Paradox: elevated energy production found in ME/CFS

Health rising blog post, by Cort Johnson, 18 April 2017: The Stanford Paradox: Elevated Energy Production Found in Chronic Fatigue Syndrome (ME/CFS)   Producing energy is a big problem in Chronic Fatigue Syndrome (ME/CFS). In fact it’s probably the problem in … Continue reading

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Myhill & McLaren-Howard discuss apparent contradictions in mitochondria research

DoctorMyhill.co.uk article, by Dr Sarah Myhill & John Howard-McLaren-Howard, 11 January 2017: Reply to Lawson Paper Background: In 2016, Nick Lawson, Chung-Han Hsieh, Dana March, Xinnan Wang published a paper with the title “Elevated Energy Production in Chronic Fatigue Syndrome … Continue reading

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Is mitochondrial function abnormal in ME/CFS?

ME Research UK article, 12 January 2017: Is mitochondrial function abnormal? Mitochondria are often referred to as the power plants of the body because they are responsible for generating nearly all the energy needed to support life. These kidney bean-shaped … Continue reading

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Elevated energy production by non-mitochondrial sources in CFS sub-group

Research abstract: Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in … Continue reading

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TRYCATS in CFS, Alzheimer’s disease and schizophrenia

Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading

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Computer simulation explores cause for exercise intolerance in ME/CFS

Research abstract: Post-exertional malaise is commonly observed in patients with myalgic encephalomyelitis/chronic fatigue syndrome, but its mechanism is not yet well understood. A reduced capacity for mitochondrial ATP synthesis is associated with the pathogenesis of CFS and is suspected to … Continue reading

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Mitochondrial dysfunction and fatigue review

Abstract Fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after physical activity. Etiologic mechanisms underlying fatigue are not well understood; however, fatigue is a hallmark symptom of mitochondrial … Continue reading

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Dr Myhill’s protocol improves mitochondrial function and fatigue

The third in a series of studies on mitochondrial function in ME/CFS has been published. Having established in the first two papers that mitochondrial dysfunction is a central pathophysiological lesion in ME/CFS, the aim of the third study  was to … Continue reading

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