Tag Archives: Dr Sonya Marshall-Gradisnik
Mast cell dysfunction in ME/CFS
Research abstract: BACKGROUND: Mast cells (MCs) mediate inflammation through neuropeptides and cytokines, along with histamine and reactive oxygen species (ROS). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an illness characterized by an unexplained disabling fatigue with multiple physiological impairments as well as … Continue reading
No difference found in difference in KIR expression in ME/CFS
Research abstract: Killer cell immunoglobulin-like receptor (KIR) genes encode for activating and inhibitory surface receptors, which are correlated with the regulation of Natural Killer (NK) cell cytotoxic activity. Reduced NK cell cytotoxic activity has been consistently reported in Chronic Fatigue … Continue reading
Epidemiological characteristics of CFS/ME in Australian patients
Research abstract: Background: No epidemiological investigations have previously been conducted in Australia according to the current clinical definitions of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The aim of this study was to describe sociodemographic and illness characteristics of Australian patients with … Continue reading
Progressive brain changes in patients with CFS
Research abstract: PURPOSE: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). MATERIALS AND METHODS: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same … Continue reading
Abnormal killer T cells found in CFS/ME and MS
Research abstract: Background: CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/ … Continue reading
A blood test can distinguish severity CFS/ME subgroups for research
Research abstract: Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe … Continue reading
Low NK cell activity differs in ME/CFS & MS
Research abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Multiple Sclerosis (MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS/ME and MS patients, dysfunction of the immune system … Continue reading
Genes disrupt signalling mechanisms in CFS
Research abstract: Background: The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles … Continue reading
Reduced cytokine levels may lead to neurological problems in CFS/ME
Research abstract Objectives: Previous research has provided evidence for dysregulation in peripheral cytokines in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date only one study has examined cytokines in cerebrospinal fluid (CSF) samples of CFS/ME patients. The purpose of … Continue reading
Severity scales in CFS/ME
Research abstract Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a physical and cognitive disabling illness, characterised by severe fatigue and a range of physiological symptoms that primarily affects women. The immense variation in clinical presentation suggests differences in severity based on … Continue reading
