Tag Archives: Dr Sonya Marshall-Gradisnik
Calcium mobilisation in natural killer cells & cell cytotoxicity in CFS/ME
Research abstract: Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+ ) cell signalling. Reduced TRPM3 has been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with … Continue reading
Six year study of abnormal brain changes in ME/CFS
ME Australia blog post, by Sasha Nimmo, 12 July 2016: Six year study of abnormal brain changes in chronic fatigue syndrome patients An Australian six year study evaluating progressive brain changes associated with chronic fatigue syndrome (Fukuda and Canadian Consensus … Continue reading
Mast cell dysfunction in ME/CFS
Research abstract: BACKGROUND: Mast cells (MCs) mediate inflammation through neuropeptides and cytokines, along with histamine and reactive oxygen species (ROS). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an illness characterized by an unexplained disabling fatigue with multiple physiological impairments as well as … Continue reading
No difference found in difference in KIR expression in ME/CFS
Research abstract: Killer cell immunoglobulin-like receptor (KIR) genes encode for activating and inhibitory surface receptors, which are correlated with the regulation of Natural Killer (NK) cell cytotoxic activity. Reduced NK cell cytotoxic activity has been consistently reported in Chronic Fatigue … Continue reading
CFS/ME cell discovery may hold key to treatment
Griffith University Media release, by Louise Durack, 9 June 2016: Chronic Fatigue Syndrome cell discovery may hold key to treatment: Chronic Fatigue Syndrome researchers have discovered a cell receptor which could be a key contributing factor to CFS, providing a … Continue reading
Epidemiological characteristics of CFS/ME in Australian patients
Research abstract: Background: No epidemiological investigations have previously been conducted in Australia according to the current clinical definitions of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The aim of this study was to describe sociodemographic and illness characteristics of Australian patients with … Continue reading
Griffith University Queensland marks ME Awareness day
Scimex article, 4 May 2016: Aussie scientists find genetic changes associated with chronic fatigue syndrome (CFS) Immunology and Immunogenetics Insights Australian researchers say they’ve found genetic changes associated with chronic fatigue syndrome (CFS, also known as Myalgic Encephalomyelitis or ME). … Continue reading
Progressive brain changes in patients with CFS
Research abstract: PURPOSE: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). MATERIALS AND METHODS: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same … Continue reading
Abnormal killer T cells found in CFS/ME and MS
Research abstract: Background: CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/ … Continue reading
A blood test can distinguish severity CFS/ME subgroups for research
Research abstract: Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe … Continue reading
