Tag Archives: mitochondrial dysfunction

The effect of ME/CFS severity on cellular bioenergetic function

Posted on 04/14/2020 by wames

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function, by Cara Tomas, Joanna L Elson, Victoria Strassheim, Julia L Newton, Mark Walker in PLoS One vol 15, #4, e0231136, April 10, 2020   Research abstract: Myalgic … Continue reading →

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Carnitine conjugation profiling in a selected cohort of patients with CFS

Posted on 02/26/2020 by wames

Carnitine conjugation profiling in a selected cohort of patients with CFS, by L Du Plessis. MSc BioChem Dissertation 2019, North West University, South Africa.  21648859   Research abstract: Chronic fatigue syndrome (CFS) is classified by the World Health Organisation (WHO) … Continue reading →

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An isolated complex V inefficiency & dysregulated mitochondrial function in immortalized lymphocytes from ME/CFS patients

Posted on 02/20/2020 by wames

An isolated complex V inefficiency and dysregulated mitochondrial function in immortalized lymphocytes from ME/CFS patients, by Daniel Missailidis, Sarah J Annesley, Claire Y Allan, Oana Sanislav, Brett A Lidbury, Donald P Lewis and Paul R Fisher in J. Mol. Sci. … Continue reading →

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MtDNA population variation in ME/CFS in two populations

Posted on 03/05/2019 by wames

MtDNA population variation in Myalgic encephalomyelitis/ Chronic fatigue syndrome in two populations: a study of mildly deleterious variants, by Marianne Venter, Cara Tomas, Ilse S Pienaar, Victoria Strassheim, Elardus Erasmus, Wan-Fai Ng, Neil Howell, Julia L Newton, Francois H Van … Continue reading →

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Changes in the transcriptome of circulating immune cells of a N Z cohort with ME/CFS

Posted on 02/01/2019 by wames

Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome, by Eiren Sweetman, Margaret Ryan, Christina Edgar, Angus MacKay, Rosamund Vallings, Warren Tate in International Journal of Immunopathology and Pharmacology vol 33 2019 [Published … Continue reading →

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A new approach to find biomarkers in CFS/ME by single-cell Raman micro-spectroscopy

Posted on 08/28/2018 by wames

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy, by Jiabao Xu,  Michelle Potter,  Cara Tomas,  Jo Elson,  Karl Morten,  Joanna Poulton,  Ning Wang, Hanqing Jin,  Zhaoxu Hou and Wei Huang in Analyst 2018 [published 22Aug 2018] Research abstract: Chronic fatigue syndrome … Continue reading →

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KPAX002 as a treatment for ME/CFS – disappointing trial results

Posted on 04/17/2018 by wames

  Research abstract: KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a prospective, randomized trial, by Jose G Montoya, Jill N Anderson, Danya L Adolphs, Lucinda Bateman, Nancy Klimas, Susan M Levine, Donn W Garvert, Jon D Kaiser … Continue reading →

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Review of potential causes of muscle dysfunction in ME/CFS

Posted on 03/02/2017 by wames

Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading →

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Myhill & McLaren-Howard discuss apparent contradictions in mitochondria research

Posted on 01/17/2017 by wames

DoctorMyhill.co.uk article, by Dr Sarah Myhill & John Howard-McLaren-Howard, 11 January 2017: Reply to Lawson Paper Background: In 2016, Nick Lawson, Chung-Han Hsieh, Dana March, Xinnan Wang published a paper with the title “Elevated Energy Production in Chronic Fatigue Syndrome … Continue reading →

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Elevated energy production by non-mitochondrial sources in CFS sub-group

Posted on 10/20/2016 by wames

Research abstract: Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in … Continue reading →

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