The role of immune responses, focussing on herpes virus specificity & interferon-gamma, in Myocardial Infarction with reperfusion & in CFS

Posted on 03/30/2020 by wames

The role of immune responses, focussing on herpes virus specificity and interferon-gamma, in Myocardial Infarction with reperfusion and in Chronic Fatigue Syndrome, by Santosh Murali. Doctoral thesis, Northumbria University, 14 January 2020

 

Research thesis abstract:

Background:
Immune responses targeting microbes can contribute to chronic inflammation, particularly when the microbes are persistent such as herpes-family Cytomegalovirus (CMV) and EpsteinBarr virus (EBV). Such persistence of antigens can cause T cell exhaustion characterized by loss of appropriate effector functions, expression of inhibitory
receptors, as well as failure to return to homeostatic pre-inflammatory conditions. This results in immune senescence and dysregulation which may cause disrupted cell populations, homing and cytokine productions that mediate immunopathology and compromise anti-microbial defences.

Aims:
The aim of the study was to determine whether microbe specific particularly, interferon gamma immune responses measured in 2 disease states, where a herpes viral inflammatory aetiology and immune dysregulation are suggested, acute Myocardial Infarction (MI) with reperfusion and Chronic Fatigue Syndrome (CFS), are indicative of
disease presence and severity.

Patients:
MI occurs due to blockage of the coronary artery, and treatment involves stent insertion, allowing reperfusion (R), which has associated immunopathology due to T cell homing. A total of 52 MI patients were studied. Blood samples were taken before and after reperfusion to investigate the dynamics of specific T cell homing to the heart, that may contribute to disease severity (reperfusion damage). For 50 CFS patients with measured disease levels, blood samples were taken to examine immune responses including those against microbes implicated in disease (CMV & EBV) compared to healthy controls.

Methods:
T cell immunity was measured by ELIspot and flow cytometry, and cytokine levels in cell culture supernatants were measured using multiplextechnology. Statistical analyses were carried out for normality in data sets. The Mann-Whitney test or unpaired t test was used to determine the difference between two unrelated groups. Differences between repeat or
paired measurements were determined by Wilcoxon signed rank tests or paired t tests. Associations between measurements were investigated using Spearman correlation.

Results and Discussion:
In MI patients, compared to before reperfusion, levels of the following cell populations fell significantly after reperfusion: terminally-differentiated CD8+ PD-1+ effector memory cells (p=0.016) and CMV-specific IFNg-secreting CD4+ T cells (p=0.002) the latter also being associated with injury. This suggests specific pathogenic T cell homing to the heart during reperfusion. In CFS patients, increased disease severity was associated with increased non-specific IFNy production (p=0.008), and reduced percentage of NK cells (p=0.0047). NK cell deficiency may reduce antiviral defences and allow detrimental viral
reactivation.

Conclusion:
T cell responses against CMV appeared to have greater involvement in MI + R than CFS. Immune responses involving IFN-gamma are demonstrated in both conditions as being associated with disease, and so this cytokine may be considered a disease biomarker and a therapeutic target for both.

Download full thesis

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ME/CFS: significant negative impact of quality of life of both patients & family members

Posted on 03/26/2020 by wames

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): significant negative impact of Quality of Life of both patients and family members, by Esme Brittain

 

During my 3rd year at Cardiff medical school, I conducted a 6-week research project looking at the impact of ME/CFS on both patients’ and their family members’ quality of life (QoL).

Background:

Our study was the first to look at the impact of ME/CFS on adult patients’ quality of life and that of their family members using validated questionnaires. Some studies have explored ME/CFS in paediatric patients and the impact on their mothers. They found that mothers experienced loss of monthly income and a marked impact on psychological health.

In another study siblings were asked to complete questionnaires and 9 siblings partook in a semi-structured interview. In the interviews, all siblings talked about restrictions on family life e.g. less holidays, don’t go out as a family as much. Some of the siblings spoke about the social stigma around ME/CF and how they had decided not to tell some of their friends about it because they may not understand. Emotional impact was also commonly talked about.

Methodology:

WAMES kindly posted information about our study on their website and social media pages. 39 patients/carers got in touch and wanted to get involved with the study, which was brilliant. We sent out a questionnaire to each patient (WHOQOL-BREF: World Health Organisation Quality of Life – Abbreviated version) and 4 questionnaires for their family members (FROM-16 – Family Reported Outcome Measures).

We had a 74% questionnaire response rate – this enabled us to achieve a robust and beneficial study.

Results:

Patients – WHOQOL-BREF

  • Patients scored very low in the physical health section, indicating this had a greater impact on their QoL.
  • There was a strong link between how the patients reported their QoL and how satisfied they were with their health i.e. the lower their health satisfaction, the poorer their QoL

Family Members – FROM-16

  • Every family member reported some degree of impact on their QoL. Our average score for ME/CFS was much higher (=poorer QoL) than studies looking at other diseases such as cancer
  • There was a strong link between the patients’ QoL and that of their family members i.e. the poorer the patients’ QoL, the greater the impact on their family members’ QoL

Conclusion:
Our study has shown ME/CFS has a major impact on both patients’ and their family members’ quality of life.  In fact studies of cancer patients and their families found their quality of life to be higher.  Could this be because there is much more support from the NHS & charities for them?  We hope clinicians will become more aware of this so that more appropriate support can be provided. Education and awareness are very important, but setting up support groups for family members could be a good start.

A larger-scale version of this study could be beneficial, as that could verify the findings and clarify the way forward for the NHS.

Watch Esme speak at the CMRC conference

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Striking the balance with epistemic injustice in healthcare: the case of CFS/ME

Posted on 03/26/2020 by wames

Striking the balance with epistemic injustice in healthcare: the case of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, by Eleanor Alexandra Byrne in Medicine, Health Care and Philosophy March 13, 2020

 

Article abstract

Miranda Fricker’s influential concept of epistemic injustice (Oxford University Press, Oxford, 2007) has recently seen application to many areas of interest, with an increasing body of healthcare research using the concept of epistemic injustice in order to develop both general frameworks and accounts of specific medical conditions and patient groups.

Testimonial injustice is unfairness related to trusting someone’s word. An injustice of this kind occurs when someone is ignored or not believed because they are a woman, because they are black, or broadly, because of their identity. Wikipedia

This paper illuminates tensions that arise between taking steps to protect against committing epistemic injustice in healthcare, and taking steps to understand the complexity of one’s predicament and treat it accordingly. Work on epistemic injustice is therefore at risk of obfuscating legitimate and potentially fruitful inquiry.

Hermeneutical injustice happens when someone’s experiences are not well understood — by themselves or by others — because these experiences do not fit any concepts known to them (or known to others), due to the historic exclusion of some groups of people from activities, such as scholarship and journalism, that shape which concepts become well known. Wikipedia

This paper uses Chronic Fatigue Syndrome/Myalgic Encephalomyelitis as a case study, but I suggest that the key problems identified could apply to other cases within healthcare,  such as those classed as Medically Unexplained Illnesses, Functional Neurological Disorders and Psychiatric Disorders.

Future work on epistemic injustice in healthcare must recognise and attend to this tension to protect against unsatisfactory attempts to correct epistemic injustice.

Extract

Kidd and Carel argue that ill persons are especially vulnerable to testimonial injustice because there is often a presumptive attribution of certain characteristics to ill persons that negatively affects the perceived credibility of their testimony, such as cognitive unreliability and emotional instability. Accordingly, patient testimonies are often dismissed as irrelevant, confused, too emotional or time-consuming (pp. 529–30).

Where there is testimonial justice in healthcare, so they argue, patient testimonies would be recognised, actively sought out, and judged to be, at least in certain respects, epistemically authoritative (p. 532). The authors state that medical professionals have epistemic authority over some matters, but that the same applies to patients, yet the various structures of medical institutions are such that the epistemic authority of the patients is often not accommodated. Kidd and Carel acknowledge occasions whereby the medical professional would be right to exercise epistemic authority, but maintain that in such cases, the clinician can often be overly dismissive (p. 531).

They also argue that ill persons are especially vulnerable to hermeneutic injustice because experiences of illness are often difficult to understand and communicate due to inadequately developed or respected hermeneutic resources (p. 529). Where there is testimonial justice, the clinician will recognise that their failing to make sense of the patient’s experience is not due to any fault of the patient. An appropriately ‘just’ clinician, they suggest, might say ‘the fact that I don’t understand you isn’t your fault but mine … I am untrained in the kind of articulacy you are using, and this hermeneutical context does not provide me with those resources’ (p. 532).

Where there is hermeneutic injustice, then, testimony is not dismissed or disbelieved outright, but there exists a conceptual impoverishment. In which case, there is a lack of epistemic resources belonging to a particular institution, or a lack of epistemic resources being appropriately employed, which prevents the patient’s articulation of their illness-experience from being acknowledged and/or shaping clinical practice. Consequently, patient’s attempts to articulate their experience are often not adequately recognised by medical professionals. In this respect, the two injustices are closely linked and work to sustain one another.

Conclusion

I have highlighted two problems with how the concept of testimonial injustice might be applied to healthcare, using the example of CFS/ME. Although a useful concept which has already aptly shown how CFS/ME patients are vulnerable to suffering from epistemic harm, I have resisted claims that identify testimonial injustices where the epistemic problem can be just as plausibly explained by the medical professional exercising appropriate medical sensitivity within the context of a vast conceptual impoverishment. I have also argued that there is a problem with the idea of the CFS/ME patient as epistemically authoritative over their first-person lived experience, since their status as ‘knower’, of even their first-person lived experience, is highly complex.

I finished by suggesting that the process of gaining epistemic insight into CFS/ME ought to be deeply collaborative. Some researchers have suggested that, in psychiatry and medicine more broadly, there ought to be more collaboration between all ‘stakeholder groups’ (Fulford et al. 2014, p. 113). There are certainly promising avenues for further careful research into what the epistemic contributions of patients can reveal about CFS/ME. In the absence of a biomedical breakthrough, collaboration between patients, researchers, clinicians and medical professionals may prove to be the most effective way to enrichen the conceptual understanding of CFS/ME, empowering both patients and medical professionals.

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Self-management of CFS in adolescents

Posted on 03/23/2020 by wames

Self-Management of Chronic Fatigue Syndrome in adolescents, by Katherine Rowe, Amanda Apple and Fiona McDonald in Paediatric Neurology [Working Title] Published online: February 28th 2020 [DOI: 10.5772/intechopen.91413]

 

Book chapter abstract:

Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a condition of unknown aetiology that commonly follows an infection. There are no known predictors for recovery or established treatments.

At the Royal Children’s Hospital (RCH) in Melbourne, Australia, the majority of young people with CFS are provided with symptom management and lifestyle guidance in an outpatient setting. However, for some, educational or social issues preclude progress and for those who request this assistance, since 2012, the Victorian Paediatric Rehabilitation Service has offered an Intensive Self-Management Program.

For this program, participants engage in both group and individual sessions, attending 3 days per week for 4 weeks in small groups of 3–4. Interdisciplinary input is from Occupational Therapy, Physiotherapy, Education and Psychology to assist with goal setting and strategies. Outcome measures are obtained at initial assessment, 6 weeks and 6 months post-program. Support is offered for 12 months post-program.

For both the outpatient program and the intensive program the outcomes and feedback from patient and family has influenced the approach and focus. This chapter outlines the current approach and how it has evolved over time.

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Peripheral endothelial dysfunction in ME/CFS

Posted on 03/19/2020 by wames

Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome, by Nadja Scherbakov, Marvin Szklarski, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Antje Meyer, Patricia Grabowski, Wolfram Doehner, Carmen Scheibenbogen in ESC Heart Failure, 10 March 2020  [https://doi.org/10.1002/ehf2.12633]

 

Research abstract:

Aims:

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. The aim of the present study was to examine peripheral endothelial function in patients with ME/CFS.

Methods and results:

Thirty‐five patients [median age 40 (range 18–70) years, mean body mass index 23.8 ± 4.2 kg/m2, 31% male] with ME/CFS were studied for peripheral endothelial function assessed by peripheral arterial tonometry (EndoPAT2000). Clinical diagnosis of ME/CFS was based on Canadian Criteria. Nine of these patients with elevated antibodies against β2‐adrenergic receptor underwent immunoadsorption and endothelial function was measured at baseline and 3, 6, and 12 months follow‐up.

ED was defined by reactive hyperaemia index ≤1.81. Twenty healthy subjects of similar age and body mass index were used as a control group. Peripheral ED was found in 18 of 35 patients (51%) with ME/CFS and in 4 healthy subjects (20%, P < 0.05). Patients with ED, in contrast to patients with normal endothelial function, reported more severe disease according to Bell score (31 ± 12 vs. 40 ± 16, P = 0.04), as well as more severe fatigue‐related symptoms (8.62 ± 0.87 vs. 7.75 ± 1.40, P = 0.04) including a higher demand for breaks [9.0 (interquartile range 7.0–10.0) vs. 7.5 (interquartile range 6.0–9.25), P = 0.04]. Peripheral ED showed correlations with more severe immune‐associated symptoms (r = −0.41, P = 0.026), such as sore throat (r = −0.38, P = 0.038) and painful lymph nodes (r = −0.37, P = 0.042), as well as more severe disease according to Bell score (r = 0.41, P = 0.008) and symptom score (r = −0.59, P = 0.005).

There were no differences between the patient group with ED and the patient group with normal endothelial function regarding demographic, metabolic, and laboratory parameters. Further, there was no difference in soluble vascular cell adhesion molecule and soluble intercellular adhesion molecule levels. At baseline, peripheral ED was observed in six patients who underwent immunoadsorption. After 12 months, endothelial function had improved in five of these six patients (reactive hyperaemia index 1.58 ± 0.15 vs. 2.02 ± 0.46, P = 0.06).

Conclusions:
Peripheral ED is frequent in patients with ME/CFS and associated with disease severity and severity of immune symptoms. As ED is a risk factor for cardiovascular disease, it is important to elucidate if peripheral ED is associated with increased cardiovascular morbidity and mortality in ME/CFS.

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Can the light of immunometabolism cut through “brain fog”?

Posted on 03/19/2020 by wames

Can the light of immunometabolism cut through “brain fog”?  by Mady Hornig in J Clin Invest. 2020;130(3):1102-1105 [doi.org/10.1172/JCI134985] First published February 10, 2020

 

Commentary abstract:

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been conclusively linked.

In this issue of the JCI, Mandarano et al. illuminate bioenergetic derangements of ME/CFS T cell subsets. CD4+ and CD8+ T cells had impaired resting glycolysis. CD8+ cells additionally showed activation-related metabolic remodeling deficits and decreased mitochondrial membrane potential; a subset had increased resting mitochondrial mass.

Immune senescence and exhaustion paradigms offer only partial explanations. Hence, unique mechanisms of disrupted immunometabolism may underlie the complex neuroimmune dysfunction of ME/CFS.

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The Role of the GP in caring for patients with ME/CFS

Posted on 03/18/2020 by wames

Cardiff University medical student Emilia Allwright tells us about her research project: 

 

In October 2019, I presented a poster for my project at the National RCGP conference. This was a wonderful opportunity to highlight ME/CFS and hopefully lead to changes in care.

As part of my medical degree, in Spring 2019, I spent 6 weeks looking at ‘The Role of the GP in caring for patients with ME/CFS’.

I was touched by the response of the ME/CFS community and so grateful to WAMES for helping me to find participants.

I was able to complete 10 telephone interviews- each participant shared their personal story which provided an amazing volume of data to use.

I went through each interview and identified key ideas and themes that formed my results:

  • Patients would appreciate having a single healthcare practitioner who would offer consistent care
  • All but one participant had experienced feeling dismissed by a GP
  • There were examples of positive relationships with GPs where both the patient and GP benefited through working together, but also where relationships had broken down

“They just need to be honest and kind and respectful and together we’ll figure out what the best way forward is.” 

“You hope to have a supportive GP because he will help you, even if he can’t treat you, he will help you.”

“And I just found it too upsetting to keep going because nothing was happening.”

“He’s just been sympathetic to what I’m going through which is a big thing.”

Conclusion:

Overall, my results emphasised the idea that a supportive GP who is honest and open with patients can make a significant impact, regardless of their ability to cure the patient.

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ME, Covid-19 & self-isolating

Posted on 03/16/2020 by wames

What do people with ME need to know about Covid-19 and self-isolating?              updated 10 April 2020

 

The Health Minister for Wales has confirmed that people over 70 and people with a range of health conditions, including  neurological conditions, should self-isolate. People with a cough and/or high temperature are asked to self isolate for 7 days. Those who have had contact with someone with confirmed Covid-19 should self-isolate for 14 days. Everybody should stay at home except for essential shopping, short daily exercise a day, essential medical needs, travelling to and from essential work, but only where this cannot be done from home. Social distancing is required by all people when outside the home.

Many people with ME have been self-isolating to some extent for years, because they have been too ill to mix with others. They will be practised in ensuring they have enough food, cleaning products, personal care items, ‘distractions’ and medications, but the coronavirus Covid-19 poses some extra problems and questions.

Much is still not known about this new virus, but some clues are emerging from US research and from the badly affected countries of China and Italy.

People don’t have to have symptoms to be infectious

  • symptoms appear 2-14 days after infection
  • infection can last weeks, up to 37 days (China)
  • people can be infectious before & after symptoms are apparent, or without symptoms
  • it is uncertain how many have no obvious symptoms and are spreading the virus
  • no symptoms doesn’t necessarily mean less able to spread the virus

Infected people without symptoms might be driving the spread of coronavirus more than we realized

 

What are the symptoms?

Regular flu has similar symptoms to COVID-19. However, COVID-19 is more likely to cause shortness of breath and other respiratory symptoms. Some people have only mild symptoms while others are very ill and struggle to breathe.

Coronavirus symptoms            Check your symptoms

 

How does the virus spread?

  • it might be airborne to a small extent
  • it definitely remains on surfaces
  • it probably doesn’t survive in water
  • it survives to some extent in faeces
  • they are unsure if it survives in sewerage systems
  • it enters the body via the eyes, nose, mouth, not through the skin
  • cats can catch it but it is uncertain if they can infect humans

Coronavirus can stay infectious for days on surfaces. But it’s still okay to check your mail

 

Who is most at risk?

Early indications in China and Italy was that the majority of people who died were over 60 with certain underlying health conditions, (but anyone can catch and pass on the virus):

  • heart disease
  • diabetes
  • hypertension – high blood pressure
  • chronic lung disease
  • some cancers

It has now become clear that younger people with no known health conditions can also be at risk.

It is unknown to what extent people with ME are at greater risk but Dr Nancy Klimas believes we could be, as ‘one of the underlying problems is that the cells protecting you against viruses are less functional because overworked.’  Dr Charles Shepherd says: ‘an infection such as this will almost certainly cause a relapse, or significant exacerbation of symptoms’.

Public health England’s updated list of those at risk & requiring social distancing,  which includes Neurological Conditions, the obese and pregnant women.

 

What distance is safe when social distancing?

It may not be possible to avoid close contact with people giving you care, or for whom you care, but all sources say where possible stay 2 metres or 6 feet away from other people. If people are moving (cyclists or runners) it may be wise to stay up to 10m away. Face masks won’t stop you catching the virus, but they may reduce the likelihood of passing it on to others.

Prof Hugh Pennington adds: “This virus needs 15 minutes of close contact with someone carrying it for you to have a reasonable chance of contracting it…But if someone who is infected coughs or sneezes on you directly then the droplets can infect you — that will be a much higher risk.”

 

How long does it last on surfaces?

When self isolating we will need to receive post, groceries etc. Are they safe? US researchers measured how long the virus stays active on various surfaces:

  • up to 24 hours on cardboard
  • up to 2 or 3 days on plastic and stainless steel.
  • it remained viable in aerosols—attached to particles that stay aloft in the air—for up to 3 hours.

Accept goods from outside, then put away perishables without contaminating other items. Either thoroughly wash the outside of the items or leave them until they are safe to touch.  Wash your hands and don’t touch your face!!

 

Can you become re-infected?

  • it is uncertain if or how long immunity lasts
  • it appears to be possible to relapse, though numbers are small
  • there are 2 variations of the virus and potentially it could mutate, though probably unlikely
  • in some countries testing for the presence of the virus may not be reliable so people only think they have recovered
  • most people recover but some experience reduced lung function following recovery, which will require some rehab
  • some concerns have been expressed that the virus may trigger an ME-like reaction as happened with SARS.

Coronavirus: can you get covid-19 twice or does it cause immunity

 

What kills the virus?

  • soap & water – dried by single use paper or warm air
  • alcohol based sprays on surfaces – leave 5 mins before wiping
  • hand sanitisers
  • chlorine
  • cooking removes any danger from food
  • bleach – disinfects, but pollutes- 5 tbsp (1/3 cup) of bleach per gallon of water

BBC: How long does the coronavirus last on surfaces?

 

When to get tested?

The UK is stepping up testing of frontline workers but still only wants to test those whose symptoms become serious due to shortage of tests – if experiencing severe symptoms ring 111 anywhere in Wales.  (Don’t press any numbers, just hold to be connected to NHS Wales, rather than NHS England)

 

How should it be treated?

Treatment for Coronavirus Disease (COVID-19)

 

How can I self-isolate?

Information on what it means to self-isolate in your home, or in a room within your home can be found on the UK Government website.  Increasingly local support schemes are being set up by concerned citizens to make it possible for people to self-isolate, even when they don’t have friends or family nearby, or access to online deliveries.

For info about how to get or give support, find your COVID-19 Facebook support group here Some Council & AVO websites list local sources of help and delivery services. Age Cymru and RVS provide support.

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Interventions to treat pain in paediatric CFS/ME: a systematic review

Posted on 03/15/2020 by wames

Interventions to treat pain in paediatric CFS/ME: a systematic review, by Caitlin Ascough, Hayley Kin, Teona Serafimova, Lucy Beasant, Sophie Jackson, Luke Baldock, Anthony Edward Pickering, Jonathan Brooks, Esther Crawley in BMJ Paediatrics Open Vol 4, #1, March 2020

 

 

What is known about the subject?

  • Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is prevalent (1%–2%) in adolescents and nearly two-thirds of patients report moderate or severe pain
  • Pain is associated with worse fatigue and poorer physical function in adolescents with CFS/ME.

What this study adds?

  • Despite the prevalence and impact of pain in children with CFS/ME few treatment studies have measured pain as an outcome and no interventions targeted pain.
  • There is insufficient evidence to suggest that the treatment of fatigue also improves pain in paediatric CFS/ME.
  • Patients who recover from CFS/ME appear to have less pain at follow-up than those who do not recover.

Research abstract:

Background
Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is common (prevalence 1%-2%). Two-thirds of children experience moderate or severe pain, which is associated with increased fatigue and poorer physical function. However, we do not know if treatment for CFS/ME improves pain.

Objective
Identify whether specialist treatment of paediatric CFS/ME improves pain.

Methods
We conducted a detailed search in MEDLINE, EMBASE, PsycINFO and the Cochrane Library. Two researchers independently screened texts published between 1994 and 24 January 2019 with no language restrictions. Inclusion criteria were (1) randomised controlled trials and observational studies; (2) participants aged <19 years with CFS/ME; and (3) measure of pain before and after an intervention.

Results
Of 1898 papers screened, 26 studies investigated treatment for paediatric CFS/ME, 19 of which did not measure pain at any time point. Only five treatment studies measured pain at baseline and follow-up and were included in this review. None of the interventions were
specifically targeted at treating pain. Of the included studies, two showed no improvement in pain scores, one suggested an improvement in one subgroup and two studies identified improvements in pain measures in ‘recovered’ patients compared with ‘non-recovered’ patients.

Conclusions
Despite the prevalence and impact of pain in children with CFS/ME surprisingly few treatment studies measured pain. In those that did measure pain, the treatments used focused on overall management of CFS/ME and we identified no treatments that were targeted specifically at managing pain. There is limited evidence that treatment helps improve pain scores. However, patients who recover appear to have less pain than those who do not recover. More studies are needed to determine if pain in paediatric CFS/ME requires a specific treatment approach, with a particular focus on patients who do not recover following initial treatment.

Read full paper (pdf)

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Cytomegalovirus, Epstein‐Barr virus, & human herpesvirus‐6 infections in patients with ME/CFS (Bulgaria)

Posted on 03/11/2020 by wames

Cytomegalovirus, Epstein‐Barr Virus and Human Herpesvirus 6 infections in patients with Myalgic Еncephalomyelitis/Chronic Fatigue Syndrome, by Evelina Shikova, Valentina Reshkova, Аntoniya Kumanova, Sevdalina Raleva,Dora Alexandrova, Natasa Capo, Modra Murovska ( on behalf of the European Network on ME/CFS (EUROMENE) in J Med Virol.  Mar 4 2020 [doi.org/10.1002/jmv.25744]

 

Research abstract:

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystem chronic disease. The etiology and pathogenesis of ME/CFS are unknown. Infections of cytomegalovirus (CMV), Epstein‐Barr virus (EBV) and human herpesvirus‐6 (HHV‐6) are suspected as etiological agents for ME/CFS.

This study aims to estimate prevalence and type (active/latent) of EBV, CMV and HHV‐6 infections in Bulgarian ME/CFS patients. In the study were included 58 ME/CFS patients and 50 healthy controls.

Virus‐specific antibodies were detected by ELISA and viral genomic sequences in PBMCs and plasma samples ‐ by nPCR. We did not observe any significant differences in virus specific IgG and IgM positivity rates between ME/CFS patients and control group. In ME/CFS plasma samples EBV DNA was found in 24.1%, CMV DNA – in 3.4% and HHV‐6 DNA in 1.7% of samples. EBV DNA was detected in 4%, CMV and HHV‐6 DNA were not found in plasma samples of controls.

The frequency of viral genome detection in PBMCs of patients and controls was 74% vs 78% for CMV, 81% vs 84% for EBV, and 82.8% vs 82% for HHV‐6. The difference in frequency of EBV active infection in ME/CFS and control group was statistically significant (p=0.0027). No ME/CFS and control individuals with active CMV and HHV‐6 infection were observed.

In conclusion, our study using both serological and PCR‐based techniques for distinguishing between active and latent infection, showed high rate of active EBV infection among ME/CFS patients indicating that at least in a subset of cases EBV is important factor for development of disease.

 

Simmaron research: Active Epstein-Barr Infections Found in Large ME/CFS Study, 18 Jul 2020

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